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Items: 3

1.

Graves disease

Graves disease is an autoimmune disorder in which antibodies to the thyrotropin receptor (TSHR; 603372) result in constitutive activation of the receptor and increased levels of thyroid hormone. Wilkin (1990) reviewed endocrine disorders of hormone excess and hormone deficiency resulting from receptor autoimmunity. [from GTR]

MedGen UID:
6677
Concept ID:
C0018213
Disease or Syndrome
2.

Graves disease

An autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones (a serious metabolic imbalance known as hyperthyroidism and thyrotoxicosis). This is caused by autoantibodies to the TSH-receptor (TSHR-Ab) that activate that TSH-receptor (TSHR), thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter). The resulting state of hyperthyroidism can cause a dramatic constellation of neuropsychological and physical signs and symptoms, which can severely compromise the patients. [from HPO]

MedGen UID:
830708
Concept ID:
CN117539
Finding
3.

Blood Loss

Loss of blood from the circulation, either internally or externally. [from NCI]

MedGen UID:
463638
Concept ID:
C3163616
Finding
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