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Items: 6

1.

Medication interaction

Alteration of the disposition and/or effect of a drug, owing to the presence of another factor such as a second drug, or food. [from NCI]

MedGen UID:
146913
Concept ID:
C0687133
Pathologic Function
2.

Rifampin

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) [from MeSH]

MedGen UID:
20586
Concept ID:
C0035608
Antibiotic; Organic Chemical
3.

Digoxin

A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04) [from NCI]

MedGen UID:
4299
Concept ID:
C0012265
Organic Chemical; Pharmacologic Substance
4.

Clinical Significance

A finding that has treatment or management implications for a patient's condition. [from NCI]

MedGen UID:
417419
Concept ID:
C2826293
Finding
5.

Hypericum perforatum extract

An herbal extract prepared from the plant Hypericum perforatum (St. John's wort) with photodynamic, antineoplastic, and antidepressant activities. Hypericin, one of the active compounds found in Hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines. Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs. [from NCI]

MedGen UID:
208822
Concept ID:
C0813171
Organic Chemical; Pharmacologic Substance
6.

Echinacea preparation

An over-the-counter herbal remedy, extracted from North American herb purple coneflower belonging to the Family Asteraceae, with potential immunostimulating and anti-inflammatory activities. Echinacea extract might be helpful to boost the body's immune system and to help fight infections, especially those of the upper respiratory tract. This herbal remedy seems to increase the growth and activity of immune cells, including white blood cells, macrophages and natural killer cells, and to stimulate phagocytosis. Furthermore, echinacoside, one of the components in Echinacea extract, has been shown to inhibit hyaluronidase, whose action increases tissue permeability, thereby Echinacea extract may promote tissue growth for wound healing by preventing bacteria spreading into healthy cells. [from NCI]

MedGen UID:
156246
Concept ID:
C0752270
Organic Chemical; Pharmacologic Substance
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