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Obesity(EO Obesity)

MedGen UID:
18127
Concept ID:
C0028754
Disease or Syndrome
Synonyms: EO Obesity; Obesity, MC4R-Related; OBESITY, SUSCEPTIBILITY TO
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: OMIM, Orphanet
Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).
Polygenic inheritance
MedGen UID:
223859
Concept ID:
C1148552
Genetic Function
Source: HPO
A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci.
Autosomal recessive inheritance (HPO, OMIM, Orphanet)
SNOMED CT: Obese (414915002); Obesity (414916001)
 
Genes (locations): ADRB2 (5q32); ADRB3 (8p11.23); AGRP (16q22.1); CARTPT (5q13.2); ENPP1 (6q23.2); GHRL (3p25.3); MC4R (18q21.32); NR0B2 (1p36.11); POMC (2p23.3); PPARG (3p25.2); PPARGC1B (5q32); SDC3 (1p35.2); SIM1 (6q16.3); UCP1 (4q31.1); UCP3 (11q13.4)
OMIM®: 601665
HPO: HP:0001513
Orphanet: ORPHA71529

Definition

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat, and/or body water. Both terms mean that a person's weight is greater than what's considered healthy for his or her height. . Obesity occurs over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active. . Being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. If you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. For example, that means losing 10 to 20 pounds if you weigh 200 pounds. NIH: National Institute of Diabetes and Digestive and Kidney Diseases.  [from MedlinePlus]

Clinical features

Obesity
MedGen UID:
368429
Concept ID:
C1963185
Finding
Decreased resting energy expenditure
MedGen UID:
868548
Concept ID:
C4022947
Finding
An reduction in the number of calories used per unit time.

Recent clinical studies

Etiology

Johnson AR, Wilkerson MD, Sampey BP, Troester MA, Hayes DN, Makowski L
Biochem Biophys Res Commun 2016 Apr 29;473(2):545-50. Epub 2016 Mar 28 doi: 10.1016/j.bbrc.2016.03.113. [Epub ahead of print] PMID: 27033600Free PMC Article
Mandviwala T, Khalid U, Deswal A
Curr Atheroscler Rep 2016 May;18(5):21. doi: 10.1007/s11883-016-0575-4. PMID: 26973130
Farrell LC, Warin MJ, Moore VM, Street JM
Soc Sci Med 2016 Apr;154:1-8. Epub 2016 Feb 18 doi: 10.1016/j.socscimed.2016.02.028. [Epub ahead of print] PMID: 26943008
Nagl M, Steinig J, Klinitzke G, Stepan H, Kersting A
Arch Womens Ment Health 2016 Apr;19(2):355-65. Epub 2015 Sep 19 doi: 10.1007/s00737-015-0573-5. [Epub ahead of print] PMID: 26386682
Bucher Della Torre S, Keller A, Laure Depeyre J, Kruseman M
J Acad Nutr Diet 2016 Apr;116(4):638-59. Epub 2015 Jul 17 doi: 10.1016/j.jand.2015.05.020. [Epub ahead of print] PMID: 26194333

Diagnosis

Mandviwala T, Khalid U, Deswal A
Curr Atheroscler Rep 2016 May;18(5):21. doi: 10.1007/s11883-016-0575-4. PMID: 26973130
Ndumele CE, Matsushita K, Sang Y, Lazo M, Agarwal SK, Nambi V, Deswal A, Blumenthal RS, Ballantyne CM, Coresh J, Selvin E
Circulation 2016 Feb 16;133(7):631-8. Epub 2016 Jan 8 doi: 10.1161/CIRCULATIONAHA.115.017298. [Epub ahead of print] PMID: 26746175Free PMC Article
Poynter JN, Richardson M, Blair CK, Roesler MA, Hirsch BA, Nguyen P, Cioc A, Warlick E, Cerhan JR, Ross JA
Cancer Epidemiol 2016 Feb;40:134-40. Epub 2015 Dec 22 doi: 10.1016/j.canep.2015.12.005. [Epub ahead of print] PMID: 26720913Free PMC Article
Moreno-Navarrete JM, Moreno M, Ortega F, Sabater M, Xifra G, Ricart W, Fernández-Real JM
Obesity (Silver Spring) 2016 Jan;24(1):139-47. doi: 10.1002/oby.21334. PMID: 26692580
Keating C, Backholer K, Gearon E, Stevenson C, Swinburn B, Moodie M, Carter R, Peeters A
Obes Res Clin Pract 2015 Nov-Dec;9(6):553-62. Epub 2015 Mar 4 doi: 10.1016/j.orcp.2015.02.004. [Epub ahead of print] PMID: 25747553

Therapy

Johnson AR, Wilkerson MD, Sampey BP, Troester MA, Hayes DN, Makowski L
Biochem Biophys Res Commun 2016 Apr 29;473(2):545-50. Epub 2016 Mar 28 doi: 10.1016/j.bbrc.2016.03.113. [Epub ahead of print] PMID: 27033600Free PMC Article
Meshram II, Vishnu Vardhana Rao M, Sudershan Rao V, Laxmaiah A, Polasa K
Br J Nutr 2016 Apr 14;115(7):1265-72. Epub 2016 Feb 12 doi: 10.1017/S0007114516000039. [Epub ahead of print] PMID: 26867590
Bucher Della Torre S, Keller A, Laure Depeyre J, Kruseman M
J Acad Nutr Diet 2016 Apr;116(4):638-59. Epub 2015 Jul 17 doi: 10.1016/j.jand.2015.05.020. [Epub ahead of print] PMID: 26194333
Littlejohn NK, Grobe JL
Am J Physiol Regul Integr Comp Physiol 2015 Dec 15;309(12):R1463-73. Epub 2015 Oct 21 doi: 10.1152/ajpregu.00224.2015. [Epub ahead of print] PMID: 26491099Free PMC Article
Juul F, Hemmingsson E
Public Health Nutr 2015 Dec;18(17):3096-107. Epub 2015 Mar 25 doi: 10.1017/S1368980015000506. [Epub ahead of print] PMID: 25804833

Prognosis

Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM
Nature 2016 May 11;533(7603):411-5. doi: 10.1038/nature17662. [Epub ahead of print] PMID: 27193687
Iannone F, Lopalco G, Rigante D, Orlando I, Cantarini L, Lapadula G
Autoimmun Rev 2016 May;15(5):447-50. Epub 2016 Jan 22 doi: 10.1016/j.autrev.2016.01.010. [Epub ahead of print] PMID: 26808074
Ndumele CE, Matsushita K, Sang Y, Lazo M, Agarwal SK, Nambi V, Deswal A, Blumenthal RS, Ballantyne CM, Coresh J, Selvin E
Circulation 2016 Feb 16;133(7):631-8. Epub 2016 Jan 8 doi: 10.1161/CIRCULATIONAHA.115.017298. [Epub ahead of print] PMID: 26746175Free PMC Article
Hosseinpanah F, Mirbolouk M, Mossadeghkhah A, Barzin M, Serahati S, Delshad H, Azizi F
Prev Med 2016 Jan;82:99-104. Epub 2015 Nov 22 doi: 10.1016/j.ypmed.2015.11.015. [Epub ahead of print] PMID: 26592692
Lundeen EA, Norris SA, Adair LS, Richter LM, Stein AD
Pediatr Obes 2016 Feb;11(1):75-80. Epub 2015 May 19 doi: 10.1111/ijpo.12039. [Epub ahead of print] PMID: 25988503Free PMC Article

Clinical prediction guides

Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL
JAMA 2016 Jun 7;315(21):2284-91. doi: 10.1001/jama.2016.6458. PMID: 27272580
Ma J, Hwang SJ, McMahon GM, Curhan GC, Mclean RR, Murabito JM, Fox CS
Obesity (Silver Spring) 2016 Feb;24(2):526-34. doi: 10.1002/oby.21356. PMID: 26813531
Ndumele CE, Matsushita K, Sang Y, Lazo M, Agarwal SK, Nambi V, Deswal A, Blumenthal RS, Ballantyne CM, Coresh J, Selvin E
Circulation 2016 Feb 16;133(7):631-8. Epub 2016 Jan 8 doi: 10.1161/CIRCULATIONAHA.115.017298. [Epub ahead of print] PMID: 26746175Free PMC Article
Hosseinpanah F, Mirbolouk M, Mossadeghkhah A, Barzin M, Serahati S, Delshad H, Azizi F
Prev Med 2016 Jan;82:99-104. Epub 2015 Nov 22 doi: 10.1016/j.ypmed.2015.11.015. [Epub ahead of print] PMID: 26592692
Juul F, Hemmingsson E
Public Health Nutr 2015 Dec;18(17):3096-107. Epub 2015 Mar 25 doi: 10.1017/S1368980015000506. [Epub ahead of print] PMID: 25804833

Recent systematic reviews

Cervoni C, Bond DS, Seng EK
Curr Pain Headache Rep 2016 Feb;20(2):13. doi: 10.1007/s11916-016-0540-5. PMID: 26862055
George MD, Baker JF
Curr Rheumatol Rep 2016 Jan;18(1):6. doi: 10.1007/s11926-015-0550-z. PMID: 26739963Free PMC Article
Bucher Della Torre S, Keller A, Laure Depeyre J, Kruseman M
J Acad Nutr Diet 2016 Apr;116(4):638-59. Epub 2015 Jul 17 doi: 10.1016/j.jand.2015.05.020. [Epub ahead of print] PMID: 26194333
Wang KS, Zuo L, Pan Y, Xie C, Luo X
J Psychiatr Res 2015 Dec;71:1-7. Epub 2015 Sep 14 doi: 10.1016/j.jpsychires.2015.09.008. [Epub ahead of print] PMID: 26522866
Allott EH, Hursting SD
Endocr Relat Cancer 2015 Dec;22(6):R365-86. Epub 2015 Sep 15 doi: 10.1530/ERC-15-0400. [Epub ahead of print] PMID: 26373570Free PMC Article

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