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1.

Imatinib

An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome. Imatinib also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF)/c-kit; the SCF/c-kit receptor tyrosine kinase is activated in gastrointestinal stromal tumor (GIST). This agent inhibits proliferation and induces apoptosis in cells that overexpress these oncoproteins. [from NCI]

MedGen UID:
183186
Concept ID:
C0935989
Organic Chemical; Pharmacologic Substance
2.

Mast cell disease, systemic

A rare disease in which too many mast cells (a type of immune system cell) are found in the skin, bones, joints, lymph nodes, liver, spleen, and gastrointestinal tract. Mast cells give off chemicals such as histamine that can cause flushing (a hot, red face), itching, abdominal cramps, muscle pain, nausea, vomiting, diarrhea, low blood pressure, and shock. [from NCI_NCI-GLOSS]

MedGen UID:
67436
Concept ID:
C0221013
Disease or Syndrome
3.

Mastocytosis

The presence of an increased number of mast cells and CD34+ mast cell precursors in the body. [from HPO]

MedGen UID:
9902
Concept ID:
C0024899
Disease or Syndrome
4.

Leukemia

Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. There are different types of leukemia, including. -Acute lymphocytic leukemia. -Acute myeloid leukemia. -Chronic lymphocytic leukemia. -Chronic myeloid leukemia. Leukemia can develop quickly or slowly. Chronic leukemia grows slowly. In acute leukemia, the cells are very abnormal and their number increases rapidly. Adults can get either type; children with leukemia most often have an acute type. Some leukemias can often be cured. Other types are hard to cure, but you can often control them. Treatments may include chemotherapy, radiation and stem cell transplantation. Even if symptoms disappear, you might need therapy to prevent a relapse. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
5.

Mastocytosis

The presence of an increased number of mast cells and CD34+ mast cell precursors in the body. [from HPO]

MedGen UID:
451849
Concept ID:
CN117388
Finding
6.

Basophilic leukemia

MedGen UID:
66376
Concept ID:
C0221292
Neoplastic Process
7.

Mast cell leukemia

A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival. [from MeSH]

MedGen UID:
44123
Concept ID:
C0023461
Neoplastic Process
8.

Eosinophilia

Increased count of eosinophils in the blood. [from HPO]

MedGen UID:
41824
Concept ID:
C0014457
Disease or Syndrome
9.

Tyrosine

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. [from MeSH]

MedGen UID:
21746
Concept ID:
C0041485
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
10.

Basophilia

Abnormally high level of basophils in the blood. [from NCI]

MedGen UID:
147328
Concept ID:
C0702266
Finding
11.

Chronic

Slow, creeping onset, slow progress and long continuance of disease manifestations. [from HPO]

MedGen UID:
104657
Concept ID:
C0205191
Temporal Concept
12.

Peripheral

On or near an edge or constituting an outer boundary; the outer area. (NCI) [from NCI_CDISC]

MedGen UID:
59959
Concept ID:
C0205100
Spatial Concept
13.

Gleevec

MedGen UID:
183185
Concept ID:
C0935987
Organic Chemical; Pharmacologic Substance
14.

Imatinib mesylate

A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors. [from MeSH]

MedGen UID:
182645
Concept ID:
C0939537
Organic Chemical; Pharmacologic Substance
15.

STI571

MedGen UID:
172122
Concept ID:
C0906802
Organic Chemical; Pharmacologic Substance
16.

Benzoate

MedGen UID:
67406
Concept ID:
C0220795
Organic Chemical; Pharmacologic Substance
17.

Connective and Soft Tissue Neoplasm

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue. [from MeSH]

MedGen UID:
60224
Concept ID:
C0206765
Neoplastic Process
18.

Neoplasm of connective tissues

Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue. [from MeSH]

MedGen UID:
45035
Concept ID:
C0027656
Neoplastic Process
19.

Myeloproliferative disorder

Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. [from HPO]

MedGen UID:
10147
Concept ID:
C0027022
Neoplastic Process
20.

Chronic Monocytic Leukemia

MedGen UID:
9729
Concept ID:
C0023466
Neoplastic Process
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