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Items: 18

1.

Interferon

Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ immunologically and in regard to some biologic and physiochemical properties. The IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10% beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha- and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570) [from NCI]

MedGen UID:
196514
Concept ID:
C0733470
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
2.

Interferon

Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. [from MeSH]

MedGen UID:
5847
Concept ID:
C0021747
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
3.

Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce. [from NCI]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
4.

Receptor Signaling

An intercellular process that involves a cellular receptor binding to a cognate ligand and results in a specific cellular response. [from NCI]

MedGen UID:
271464
Concept ID:
C1514762
Molecular Function
5.

Immune

Protected against infectious disease by either specific or non-specific mechanisms.(On-line Medical Dictionary) [from NCI]

MedGen UID:
98553
Concept ID:
C0439662
Finding
6.

Triglyceride storage disease with ichthyosis

Chanarin-Dorfman syndrome is a condition in which fats (lipids) are stored abnormally in the body. Affected individuals cannot break down certain fats called triglycerides, and these fats accumulate in organs and tissues, including skin, liver, muscles, intestine, eyes, and ears. People with this condition also have dry, scaly skin (ichthyosis), which is usually present at birth. Additional features of this condition include an enlarged liver (hepatomegaly), clouding of the lens of the eyes (cataracts), difficulty with coordinating movements (ataxia), hearing loss, short stature, muscle weakness (myopathy), involuntary movement of the eyes (nystagmus), and mild intellectual disability.The signs and symptoms vary greatly among individuals with Chanarin-Dorfman syndrome. Some people may have ichthyosis only, while others may have problems affecting many areas of the body. [from GTR]

MedGen UID:
82780
Concept ID:
C0268238
Disease or Syndrome
7.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
8.

Fiblaferon

A non-recombinant from of Interferon-beta. [from MeSH]

MedGen UID:
196534
Concept ID:
C0733567
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
9.

Disease due to Paramyxoviridae

Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. [from MeSH]

MedGen UID:
104899
Concept ID:
C0206613
Disease or Syndrome
10.

Mononegavirales Infections

Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS. [from MeSH]

MedGen UID:
67005
Concept ID:
C0242916
Disease or Syndrome
11.

Disease due to Pneumovirus

Infections with viruses of the genus PNEUMOVIRUS, family PARAMYXOVIRIDAE. This includes RESPIRATORY SYNCYTIAL VIRUS INFECTIONS, an important cause of respiratory disease in humans. [from MeSH]

MedGen UID:
61643
Concept ID:
C0206615
Disease or Syndrome
12.

Viral disease

A general term for diseases caused by viruses. [from MeSH]

MedGen UID:
53027
Concept ID:
C0042769
Disease or Syndrome
13.

Respiratory syncytial virus infection

Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children. [from NCI]

MedGen UID:
48424
Concept ID:
C0035235
Disease or Syndrome
14.

UPREG

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
12003
Concept ID:
C0041904
Molecular Function
15.

RNA Virus Infections

Diseases caused by RNA VIRUSES. [from MeSH]

MedGen UID:
11250
Concept ID:
C0035690
Disease or Syndrome
16.

Parainfluenza

MedGen UID:
10567
Concept ID:
C0030389
Disease or Syndrome
17.

Interferon Type I

Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA). [from MeSH]

MedGen UID:
9509
Concept ID:
C0021743
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
18.

Interferon beta

A class of interferon elaborated by fibroblasts. [from NCI]

MedGen UID:
5171
Concept ID:
C0015980
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
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