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Items: 7

1.

Olanzapine

A synthetic derivative of thienobenzodiazepine with antipsychotic, antinausea, and antiemetic activities. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. The antinausea and antiemetic effects of this agent appear to be due to the blockade of 5-HT2 and 5-HT3 receptors for serotonin. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through antagonism to dopamine D2 receptors with rapid ligand-receptor dissociation kinetics that help to minimize extrapyramidal symptoms (EPS). Olanzapine may also stimulate appetite. [from NCI]

MedGen UID:
104292
Concept ID:
C0171023
Organic Chemical; Pharmacologic Substance
2.

Emergil

MedGen UID:
148655
Concept ID:
C0700804
Organic Chemical; Pharmacologic Substance
3.

Thioxanthenes

Compounds with three aromatic rings in linear arrangement with a SULFUR in the center ring. [from MeSH]

MedGen UID:
52728
Concept ID:
C0039961
Organic Chemical; Pharmacologic Substance
4.

Fluanxol

MedGen UID:
42043
Concept ID:
C0016272
Organic Chemical; Pharmacologic Substance
5.

Prolixin

MedGen UID:
18671
Concept ID:
C0033390
Organic Chemical; Pharmacologic Substance
6.

Fluphenazine

A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE. [from MeSH]

MedGen UID:
8870
Concept ID:
C0016368
Organic Chemical; Pharmacologic Substance
7.

Flupentixol

A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595) [from MeSH]

MedGen UID:
8869
Concept ID:
C0016367
Organic Chemical; Pharmacologic Substance
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