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Items: 1 to 20 of 42

1.

Carcinogenesis

A pathological process in which normal cells are transformed into malignant cancer cells within a primary tumor. [from NCI]

MedGen UID:
154544
Concept ID:
C0596263
Neoplastic Process
2.

Barrett esophagus

An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system. [from HPO]

MedGen UID:
506488
Concept ID:
CN117473
Finding
3.

Barrett esophagus

Barrett esophagus, or Barrett metaplasia, describes the phenotypic change of normal esophageal squamous epithelium to a columnar and intestinal-type epithelium. This metaplastic change is important because patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett metaplasia is gastroesophageal reflux (GER; 109350). The retrograde movement of acid and bile salts from the stomach into the esophagus in this disease causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes (summary by Wong et al., 2005). [from GTR]

MedGen UID:
2551
Concept ID:
C0004763
Disease or Syndrome
4.

Malignancies

MedGen UID:
924235
Concept ID:
C4282132
Neoplastic Process
5.

DNA Methylation

The process by which methyl groups are added to nucleotides in genomic DNA. [from NCI]

MedGen UID:
138191
Concept ID:
C0376452
Molecular Function
6.

Condition, Preneoplastic

cellular state in which there is evidence of intracellular changes which could lead to a neoplastic condition. [from CRISP]

MedGen UID:
129147
Concept ID:
C0282313
Neoplastic Process
7.

Methylation

The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI) [from NCI]

MedGen UID:
44400
Concept ID:
C0025723
Molecular Function
8.

Cisplatin

An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. [from NCI]

MedGen UID:
40318
Concept ID:
C0008838
Inorganic Chemical; Pharmacologic Substance
9.

Adenocarcinoma

A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. [from NCI]

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
10.

Suppression

MedGen UID:
526147
Concept ID:
C0221103
Pathologic Function
11.

Familial multiple trichoepitheliomata

Multiple familial trichoepithelioma, also called epithelioma adenoides cysticum (EAC), is an autosomal dominant dermatosis characterized by the presence of many skin tumors predominantly on the face. Since histologic examination shows dermal aggregates of basaloid cells with connection to or differentiation toward hair follicles, this disorder has been thought to represent a benign hamartoma of the pilosebaceous apparatus. Trichoepitheliomas can degenerate into basal cell carcinoma (Johnson and Bennett, 1993). Because BRSS, familial cylindromatosis, and MFT1 are allelic, and because different manifestations of each have been described within a single family, many consider these disorders to represent a phenotypic spectrum of a single disease entity (Lee et al., 2005; Bowen et al., 2005; Young et al., 2006; Saggar et al., 2008). Blake and Toro (2009) provided a detailed review of the spectrum of disorders associated with CYLD mutations. [from GTR]

MedGen UID:
220890
Concept ID:
C1275122
Neoplastic Process
12.

Esophageal Adenocarcinoma

A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor. [from NCI]

MedGen UID:
124636
Concept ID:
C0279628
Neoplastic Process
13.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
14.

Platinol

MedGen UID:
195927
Concept ID:
C0699666
Inorganic Chemical; Pharmacologic Substance
15.

NSC-119875

MedGen UID:
181696
Concept ID:
C0936226
Inorganic Chemical; Pharmacologic Substance
16.

Platino

MedGen UID:
152100
Concept ID:
C0699665
Inorganic Chemical; Pharmacologic Substance
17.

Platidiam

MedGen UID:
152099
Concept ID:
C0699664
Inorganic Chemical; Pharmacologic Substance
18.

Biocisplatinum

MedGen UID:
152098
Concept ID:
C0699663
Inorganic Chemical; Pharmacologic Substance
19.

Course of illness

The worsening of a disease over time. [from NCI]

MedGen UID:
116631
Concept ID:
C0242656
Pathologic Function
20.

Carcinomatosis

Carcinoma that has spread diffusely to an anatomic site or throughout the body. [from NCI]

MedGen UID:
104704
Concept ID:
C0205699
Neoplastic Process
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