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Somatostatin

MedGen UID:
11505
Concept ID:
C0037659
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
Synonyms: Cyclic Somatostatin; Somatostatin 14; Somatostatin, Cyclic; Somatostatin-14; Somatotropin Release Inhibiting Factor; Somatotropin Release Inhibiting Hormone; Somatotropin Release-Inhibiting Factor; Somatotropin Release-Inhibiting Hormone; SRIH-14
SNOMED CT: Growth hormone release inhibiting hormone (49722008); SS - Somatostatin (49722008); Somatotropin inhibiting factor preparation (57819002); Somatostatin-14 (49722008); Somatotropin release inhibiting factor (49722008); Somatostatin (49722008); Growth hormone inhibiting factor (49722008); SRIF (49722008); Somatostatin preparation (57819002)
 

Definition

Expressed primarily by human SST Gene (Somatostatin Family) in the hypothalamic median eminence and in pancreatic delta cells, secreted 116-aa 13-kDa (precursor) Somatostatin is an important cyclic tetradecapeptide regulator of endocrine and nervous system function. Somatostatin inhibits release of adenohypophyseal GH, thyrotropin, and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal mucosal secretin, and renal renin by binding to specific high-affinity cell surface G protein-coupled receptors expressed in a tissue-specific manner. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSomatostatin

Recent clinical studies

Etiology

Zhou Y, Wang L, Huang X, Li H, Xiong Y
J Ethnopharmacol 2016 Dec 24;194:495-505. Epub 2016 Sep 29 doi: 10.1016/j.jep.2016.09.053. PMID: 27693773
Hung TH, Tsai CC, Tseng CW, Tseng KC, Hsieh YH, Tsai CC
Eur J Gastroenterol Hepatol 2016 Nov;28(11):1275-9. doi: 10.1097/MEG.0000000000000703. PMID: 27455080Free PMC Article
Zawada NB, Kunert-Radek J, Pawlikowski M, Pisarek H, Radek M
Endokrynol Pol 2016;67(3):292-8. Epub 2016 Jun 27 doi: 10.5603/EP.a2016.0043. PMID: 27345147
Wang G, Liu Y, Zhou SF, Qiu P, Xu L, Wen P, Wen J, Xiao X
Am J Med Sci 2016 May;351(5):506-12. Epub 2016 Mar 31 doi: 10.1016/j.amjms.2016.03.013. PMID: 27140710
Gatto F, Biermasz NR, Feelders RA, Kros JM, Dogan F, van der Lely AJ, Neggers SJ, Lamberts SW, Pereira AM, Ferone D, Hofland LJ
Eur J Endocrinol 2016 May;174(5):651-62. Epub 2016 Feb 17 doi: 10.1530/EJE-15-0391. PMID: 26888629

Diagnosis

Yarman S, Yalın GY, Dogansen SC, Canbaz B, Tanrıkulu S, Akyuz F
J Clin Pharm Ther 2016 Oct;41(5):559-62. Epub 2016 Jul 6 doi: 10.1111/jcpt.12412. PMID: 27380906
Zawada NB, Kunert-Radek J, Pawlikowski M, Pisarek H, Radek M
Endokrynol Pol 2016;67(3):292-8. Epub 2016 Jun 27 doi: 10.5603/EP.a2016.0043. PMID: 27345147
Salavati A, Puranik A, Kulkarni HR, Budiawan H, Baum RP
Semin Nucl Med 2016 May;46(3):215-24. doi: 10.1053/j.semnuclmed.2016.01.010. PMID: 27067502
Günther T, Culler M, Schulz S
Mol Endocrinol 2016 Apr;30(4):479-90. Epub 2016 Mar 11 doi: 10.1210/me.2015-1241. PMID: 26967369Free PMC Article
Gevers TJ, Nevens F, Torres VE, Hogan MC, Drenth JP
Liver Int 2016 Apr;36(4):595-602. Epub 2015 Nov 9 doi: 10.1111/liv.12986. PMID: 26481454

Therapy

Zhou Y, Wang L, Huang X, Li H, Xiong Y
J Ethnopharmacol 2016 Dec 24;194:495-505. Epub 2016 Sep 29 doi: 10.1016/j.jep.2016.09.053. PMID: 27693773
Yarman S, Yalın GY, Dogansen SC, Canbaz B, Tanrıkulu S, Akyuz F
J Clin Pharm Ther 2016 Oct;41(5):559-62. Epub 2016 Jul 6 doi: 10.1111/jcpt.12412. PMID: 27380906
Wang G, Liu Y, Zhou SF, Qiu P, Xu L, Wen P, Wen J, Xiao X
Am J Med Sci 2016 May;351(5):506-12. Epub 2016 Mar 31 doi: 10.1016/j.amjms.2016.03.013. PMID: 27140710
Abdellatif AA, Zayed G, El-Bakry A, Zaky A, Saleem IY, Tawfeek HM
Drug Dev Ind Pharm 2016 Nov;42(11):1782-91. Epub 2016 May 5 doi: 10.3109/03639045.2016.1173052. PMID: 27032509
Gevers TJ, Nevens F, Torres VE, Hogan MC, Drenth JP
Liver Int 2016 Apr;36(4):595-602. Epub 2015 Nov 9 doi: 10.1111/liv.12986. PMID: 26481454

Prognosis

Yarman S, Yalın GY, Dogansen SC, Canbaz B, Tanrıkulu S, Akyuz F
J Clin Pharm Ther 2016 Oct;41(5):559-62. Epub 2016 Jul 6 doi: 10.1111/jcpt.12412. PMID: 27380906
Wang G, Liu Y, Zhou SF, Qiu P, Xu L, Wen P, Wen J, Xiao X
Am J Med Sci 2016 May;351(5):506-12. Epub 2016 Mar 31 doi: 10.1016/j.amjms.2016.03.013. PMID: 27140710
Gatto F, Biermasz NR, Feelders RA, Kros JM, Dogan F, van der Lely AJ, Neggers SJ, Lamberts SW, Pereira AM, Ferone D, Hofland LJ
Eur J Endocrinol 2016 May;174(5):651-62. Epub 2016 Feb 17 doi: 10.1530/EJE-15-0391. PMID: 26888629
Gevers TJ, Nevens F, Torres VE, Hogan MC, Drenth JP
Liver Int 2016 Apr;36(4):595-602. Epub 2015 Nov 9 doi: 10.1111/liv.12986. PMID: 26481454
Colao A, Auriemma RS, Pivonello R
Pituitary 2016 Apr;19(2):210-21. doi: 10.1007/s11102-015-0677-y. PMID: 26290466Free PMC Article

Clinical prediction guides

Zhou Y, Wang L, Huang X, Li H, Xiong Y
J Ethnopharmacol 2016 Dec 24;194:495-505. Epub 2016 Sep 29 doi: 10.1016/j.jep.2016.09.053. PMID: 27693773
Yarman S, Yalın GY, Dogansen SC, Canbaz B, Tanrıkulu S, Akyuz F
J Clin Pharm Ther 2016 Oct;41(5):559-62. Epub 2016 Jul 6 doi: 10.1111/jcpt.12412. PMID: 27380906
Wang G, Liu Y, Zhou SF, Qiu P, Xu L, Wen P, Wen J, Xiao X
Am J Med Sci 2016 May;351(5):506-12. Epub 2016 Mar 31 doi: 10.1016/j.amjms.2016.03.013. PMID: 27140710
Gevers TJ, Nevens F, Torres VE, Hogan MC, Drenth JP
Liver Int 2016 Apr;36(4):595-602. Epub 2015 Nov 9 doi: 10.1111/liv.12986. PMID: 26481454
Colao A, Auriemma RS, Pivonello R
Pituitary 2016 Apr;19(2):210-21. doi: 10.1007/s11102-015-0677-y. PMID: 26290466Free PMC Article

Recent systematic reviews

Zhou Y, Wang L, Huang X, Li H, Xiong Y
J Ethnopharmacol 2016 Dec 24;194:495-505. Epub 2016 Sep 29 doi: 10.1016/j.jep.2016.09.053. PMID: 27693773
Colao A, Auriemma RS, Pivonello R, Kasuki L, Gadelha MR
Pituitary 2016 Jun;19(3):235-47. doi: 10.1007/s11102-015-0684-z. PMID: 26519143Free PMC Article
Qin X, Lei WS, Xing ZX, Shi F
Saudi J Gastroenterol 2015 Nov-Dec;21(6):372-8. doi: 10.4103/1319-3767.167187. PMID: 26655132Free PMC Article
Jin K, Zhou H, Zhang J, Wang W, Sun Y, Ruan C, Hu Z, Wang Y
Dig Surg 2015;32(3):196-207. doi: 10.1159/000381032. PMID: 25872003
Zhang L, Wu X, Yan Y, Qian J, Lu Y, Luo C
Brain Dev 2015 Feb;37(2):181-90. Epub 2014 May 10 doi: 10.1016/j.braindev.2014.04.009. PMID: 24815226

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