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Anxiety

MedGen UID:
335849
Concept ID:
C1842981
Mental or Behavioral Dysfunction
Synonyms: Neuroticism; Neuroticism Trait; Neuroticism Traits
 
Gene (location): SLC6A4 (17q11.2)
OMIM®: 607834

Definition

Human personality is shaped by genetic and environmental factors, and evidence suggests that the genetic component is highly complex, polygenic, and epistatic. Genetic factors are thought to contribute to 40 to 60% of trait variance. Molecular genetics has tried to identify specific genes for quantitative traits, called quantitative trait loci (QTLs). The QTL concept suggests that complex personality traits or dimensions are not attributable to single genes, but to multiple interacting genes (Reif and Lesch, 2003). Fullerton et al. (2003) stated that psychologists were in agreement that the wide variation in human personalities can be explained by a small number of personality factors, including neuroticism (a measure of emotional stability), which manifests at one extreme as anxiety, depression, moodiness, low self-esteem, and diffidence. They cited a number of studies that had described a relationship between high scores on measures of neuroticism and major depressive disorder. They also noted that theoretical studies had suggested that large samples of randomly ascertained sibs could be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. See also panic disorder (PAND1; 167870), which is a subtype of anxiety disorder. [from OMIM]

Recent clinical studies

Etiology

Altino DM, Nogueira-Martins LA, de Barros ALBL, Lopes JL
Arch Psychiatr Nurs 2017 Dec;31(6):549-552. Epub 2017 Jul 21 doi: 10.1016/j.apnu.2017.07.004. PMID: 29179819
Buzzell GA, Troller-Renfree SV, Barker TV, Bowman LC, Chronis-Tuscano A, Henderson HA, Kagan J, Pine DS, Fox NA
J Am Acad Child Adolesc Psychiatry 2017 Dec;56(12):1097-1105. Epub 2017 Oct 13 doi: 10.1016/j.jaac.2017.10.007. PMID: 29173744
Williams R, Leone L, Faedda N, Natalucci G, Bellini B, Salvi E, Verdecchia P, Cerutti R, Arruda M, Guidetti V
J Headache Pain 2017 Dec;18(1):62. Epub 2017 May 30 doi: 10.1186/s10194-017-0769-3. PMID: 28560542Free PMC Article
Peres MFP, Mercante JPP, Tobo PR, Kamei H, Bigal ME
J Headache Pain 2017 Dec;18(1):37. Epub 2017 Mar 21 doi: 10.1186/s10194-017-0742-1. PMID: 28324317Free PMC Article
Newby JM, Mewton L, Andrews G
J Anxiety Disord 2017 Mar;46:25-34. Epub 2016 Jun 23 doi: 10.1016/j.janxdis.2016.06.002. PMID: 27396841

Diagnosis

Muschalla B, Jöbges M
Arch Phys Med Rehabil 2018 Jan;99(1):57-64. Epub 2017 Jul 20 doi: 10.1016/j.apmr.2017.06.017. PMID: 28735718
Buzzell GA, Troller-Renfree SV, Barker TV, Bowman LC, Chronis-Tuscano A, Henderson HA, Kagan J, Pine DS, Fox NA
J Am Acad Child Adolesc Psychiatry 2017 Dec;56(12):1097-1105. Epub 2017 Oct 13 doi: 10.1016/j.jaac.2017.10.007. PMID: 29173744
Williams R, Leone L, Faedda N, Natalucci G, Bellini B, Salvi E, Verdecchia P, Cerutti R, Arruda M, Guidetti V
J Headache Pain 2017 Dec;18(1):62. Epub 2017 May 30 doi: 10.1186/s10194-017-0769-3. PMID: 28560542Free PMC Article
Taylor CT, Pearlstein SL, Stein MB
J Anxiety Disord 2017 Jun;49:21-30. Epub 2017 Mar 31 doi: 10.1016/j.janxdis.2017.03.007. PMID: 28384621Free PMC Article
Peres MFP, Mercante JPP, Tobo PR, Kamei H, Bigal ME
J Headache Pain 2017 Dec;18(1):37. Epub 2017 Mar 21 doi: 10.1186/s10194-017-0742-1. PMID: 28324317Free PMC Article

Therapy

Michelsen B, Kristianslund EK, Sexton J, Hammer HB, Fagerli KM, Lie E, Wierød A, Kalstad S, Rødevand E, Krøll F, Haugeberg G, Kvien TK
Ann Rheum Dis 2017 Nov;76(11):1906-1910. Epub 2017 Jul 21 doi: 10.1136/annrheumdis-2017-211284. PMID: 28733473
Trambert R, Kowalski MO, Wu B, Mehta N, Friedman P
Worldviews Evid Based Nurs 2017 Oct;14(5):394-402. Epub 2017 Apr 10 doi: 10.1111/wvn.12229. PMID: 28395396
Taylor CT, Pearlstein SL, Stein MB
J Anxiety Disord 2017 Jun;49:21-30. Epub 2017 Mar 31 doi: 10.1016/j.janxdis.2017.03.007. PMID: 28384621Free PMC Article
Fard FE, Mirghafourvand M, Mohammad-Alizadeh Charandabi S, Farshbaf-Khalili A, Javadzadeh Y, Asgharian H
Women Health 2017 Oct;57(9):1115-1128. Epub 2016 Sep 12 doi: 10.1080/03630242.2016.1235074. PMID: 27617502
Newby JM, Mewton L, Andrews G
J Anxiety Disord 2017 Mar;46:25-34. Epub 2016 Jun 23 doi: 10.1016/j.janxdis.2016.06.002. PMID: 27396841

Prognosis

Altino DM, Nogueira-Martins LA, de Barros ALBL, Lopes JL
Arch Psychiatr Nurs 2017 Dec;31(6):549-552. Epub 2017 Jul 21 doi: 10.1016/j.apnu.2017.07.004. PMID: 29179819
Buzzell GA, Troller-Renfree SV, Barker TV, Bowman LC, Chronis-Tuscano A, Henderson HA, Kagan J, Pine DS, Fox NA
J Am Acad Child Adolesc Psychiatry 2017 Dec;56(12):1097-1105. Epub 2017 Oct 13 doi: 10.1016/j.jaac.2017.10.007. PMID: 29173744
Michelsen B, Kristianslund EK, Sexton J, Hammer HB, Fagerli KM, Lie E, Wierød A, Kalstad S, Rødevand E, Krøll F, Haugeberg G, Kvien TK
Ann Rheum Dis 2017 Nov;76(11):1906-1910. Epub 2017 Jul 21 doi: 10.1136/annrheumdis-2017-211284. PMID: 28733473
Taylor CT, Pearlstein SL, Stein MB
J Anxiety Disord 2017 Jun;49:21-30. Epub 2017 Mar 31 doi: 10.1016/j.janxdis.2017.03.007. PMID: 28384621Free PMC Article
Peres MFP, Mercante JPP, Tobo PR, Kamei H, Bigal ME
J Headache Pain 2017 Dec;18(1):37. Epub 2017 Mar 21 doi: 10.1186/s10194-017-0742-1. PMID: 28324317Free PMC Article

Clinical prediction guides

Muschalla B, Jöbges M
Arch Phys Med Rehabil 2018 Jan;99(1):57-64. Epub 2017 Jul 20 doi: 10.1016/j.apmr.2017.06.017. PMID: 28735718
Buzzell GA, Troller-Renfree SV, Barker TV, Bowman LC, Chronis-Tuscano A, Henderson HA, Kagan J, Pine DS, Fox NA
J Am Acad Child Adolesc Psychiatry 2017 Dec;56(12):1097-1105. Epub 2017 Oct 13 doi: 10.1016/j.jaac.2017.10.007. PMID: 29173744
Taylor CT, Pearlstein SL, Stein MB
J Anxiety Disord 2017 Jun;49:21-30. Epub 2017 Mar 31 doi: 10.1016/j.janxdis.2017.03.007. PMID: 28384621Free PMC Article
Peres MFP, Mercante JPP, Tobo PR, Kamei H, Bigal ME
J Headache Pain 2017 Dec;18(1):37. Epub 2017 Mar 21 doi: 10.1186/s10194-017-0742-1. PMID: 28324317Free PMC Article
Newby JM, Mewton L, Andrews G
J Anxiety Disord 2017 Mar;46:25-34. Epub 2016 Jun 23 doi: 10.1016/j.janxdis.2016.06.002. PMID: 27396841

Recent systematic reviews

Lazor T, Tigelaar L, Pole JD, De Souza C, Tomlinson D, Sung L
Support Care Cancer 2017 Sep;25(9):2921-2931. Epub 2017 Jun 3 doi: 10.1007/s00520-017-3743-3. PMID: 28578534
Sucala M, Cuijpers P, Muench F, Cardoș R, Soflau R, Dobrean A, Achimas-Cadariu P, David D
Depress Anxiety 2017 Jun;34(6):518-525. Epub 2017 May 15 doi: 10.1002/da.22654. PMID: 28504859
Cooney LG, Lee I, Sammel MD, Dokras A
Hum Reprod 2017 May 1;32(5):1075-1091. doi: 10.1093/humrep/dex044. PMID: 28333286
Chen PY, Liu YM, Chen ML
Worldviews Evid Based Nurs 2017 Jun;14(3):223-236. Epub 2017 Mar 7 doi: 10.1111/wvn.12215. PMID: 28267893
Hallford DJ, Nicholson G, Sanders K, McCabe MP
J Gerontol B Psychol Sci Soc Sci 2017 Sep 1;72(5):729-741. doi: 10.1093/geronb/gbv160. PMID: 26791279

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