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Items: 4

1.

Malignant tumor of prostate

A cancer of the prostate. [from HPO]

MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
2.

Finasteride

A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. [from NCI]

MedGen UID:
29013
Concept ID:
C0060389
Hormone; Organic Chemical; Pharmacologic Substance
3.

Prostate cancer

A cancer of the prostate. [from HPO]

MedGen UID:
506673
Concept ID:
CN167851
Finding
4.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
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