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Items: 17

1.

Dehydroepiandrosterone sulfate

The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. [from MeSH]

MedGen UID:
27975
Concept ID:
C0057277
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
2.

21-Deoxycortisol

MedGen UID:
24207
Concept ID:
C0046639
Organic Chemical; Pharmacologic Substance
3.

Dehydroepiandrosterone preparation

A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. [from MeSH]

MedGen UID:
4171
Concept ID:
C0011185
Hormone; Organic Chemical; Pharmacologic Substance
4.

Androstenedione

A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. [from MeSH]

MedGen UID:
1914
Concept ID:
C0002860
Hormone; Organic Chemical; Pharmacologic Substance
5.

Adrenal Androgen Excess

Excessive secretion of the androgen hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Clinical manifestations may include virilization.(NICHD) [from NCI]

MedGen UID:
824345
Concept ID:
C3831597
Finding
6.

Androgen excess

Excessive secretion of androgens from the adrenal glands or gonads. Clinical manifestations may include virilization.(NICHD) [from NCI]

MedGen UID:
810567
Concept ID:
C0235461
Finding
7.

21-hydroxylase deficiency

21-hydroxylase deficiency (21-OHD) is the most common cause of congenital adrenal hyperplasia (CAH), a family of autosomal recessive disorders involving impaired synthesis of cortisol from cholesterol by the adrenal cortex. In 21-OHD CAH, excessive adrenal androgen biosynthesis results in virilization in all individuals and salt wasting in some individuals. A classic form with severe enzyme deficiency and prenatal onset of virilization is distinguished from a non-classic form with mild enzyme deficiency and postnatal onset. The classic form is further divided into the simple virilizing form (~25% of affected individuals) and the salt-wasting form, in which aldosterone production is inadequate (=75% of individuals). Newborns with salt-wasting 21-OHD CAH are at risk for life-threatening salt-wasting crises. Individuals with the non-classic form of 21-OHD CAH present postnatally with signs of hyperandrogenism; females with the non-classic form are not virilized at birth. [from GTR]

MedGen UID:
468578
Concept ID:
C0852654
Disease or Syndrome
8.

Maternal

A designation that has some relationship to motherhood. [from NCI]

MedGen UID:
348949
Concept ID:
C1858460
Finding
9.

Genetic predisposition

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. [from MeSH]

MedGen UID:
137259
Concept ID:
C0314657
Organism Attribute
10.

Multiple endocrine neoplasia

A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively. [from MeSH]

MedGen UID:
45036
Concept ID:
C0027662
Neoplastic Process
11.

Sex hormone

A class of steroid hormones that specifically binds to and activates androgen, progesterone or estrogen receptors. Sex steroids activate various signaling pathways involved in the development and maintenance of secondary sexual characteristics, reproductive processes, blood salt balance, response to stress, neuronal function and a number of metabolic processes. [from NCI]

MedGen UID:
19951
Concept ID:
C0036884
Hormone; Pharmacologic Substance
12.

Hydrocortisone

A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04) [from NCI]

MedGen UID:
9337
Concept ID:
C0020268
Hormone; Organic Chemical; Pharmacologic Substance
13.

Androgenic preparation

A synthetic or animal-derived hormone that is chemically or functionally similar or identical to endogenous androgen with potential use in therapeutic applications. [from NCI]

MedGen UID:
8060
Concept ID:
C0002844
Hormone; Pharmacologic Substance
14.

Homosexuality, Ego-Dystonic

MedGen UID:
9298
Concept ID:
C0019899
Mental or Behavioral Dysfunction
15.

Heredity

The transmission of traits encoded in GENES from parent to offspring. [from MeSH]

MedGen UID:
6814
Concept ID:
C0019266
Molecular Function
16.

6-diethylaminomethylcholest-5-ene-3 beta-ol

MedGen UID:
113490
Concept ID:
C0606772
Organic Chemical; Pharmacologic Substance
17.

Cortisol level normal

MedGen UID:
663339
Concept ID:
C0580459
Finding
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