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Items: 5

1.

Lonafarnib

A synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. (NCI04) [from NCI]

MedGen UID:
263333
Concept ID:
C1257385
Organic Chemical; Pharmacologic Substance
2.

Brain neoplasm

MedGen UID:
910838
Concept ID:
CN241425
Finding
3.

Central

Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure. [from HPO]

MedGen UID:
59958
Concept ID:
C0205099
Spatial Concept
4.

Neoplasm of brain

A benign or malignant neoplasm that arises from or metastasizes to the brain. [from HPO]

MedGen UID:
14216
Concept ID:
C0006118
Neoplastic Process
5.

Farnesylation Inhibition

Farnesylation Inhibition involves interference with, or restraint of, enzymatic activities involved in covalent addition of farnesyl group(s) (three isoprene units) to polypeptide chains that contain the C terminal motif CAAX after assembly from messenger RNA at the ribosome. [from NCI]

MedGen UID:
273297
Concept ID:
C1517133
Molecular Function
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