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Items: 6

1.

aliskiren

An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in the renin-angiotensin-aldosterone system (RAAS) that is responsible for converting angiotensinogen to angiotensin I (AT I). By inhibiting the activity of renin, the conversion to AT I is prevented, which in turn prevents the conversion of AT I to AT II. This prevents arterial vasoconstriction by AT II and inhibits the production of aldosterone by AT II. As aldosterone causes re-uptake of sodium and water and eventually an increase in extracellular volume, aliskiren is able to prevent the effects that contribute to an increase in blood pressure. [from NCI]

MedGen UID:
205157
Concept ID:
C1120110
Organic Chemical; Pharmacologic Substance
2.

Disorder of cardiovascular system

Any abnormality of the cardiovascular system. [from HPO]

MedGen UID:
2848
Concept ID:
C0007222
Disease or Syndrome
3.

Interlabial Escape; No Progression to Anterior Lip

A finding of interlabial escape during swallowing, but no progression to anterior lip. [from NCI]

MedGen UID:
926412
Concept ID:
C4288880
Finding
4.

Cardiovascular Diseases

MedGen UID:
881028
Concept ID:
CN236672
Disease or Syndrome
5.

Bilateral renal artery stenosis

MedGen UID:
678556
Concept ID:
C0856760
Disease or Syndrome
6.

Aliskiren fumarate

An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in the renin-angiotensin-aldosterone system (RAAS) that is responsible for converting angiotensinogen to angiotensin I (AT I). By inhibiting the activity of renin, the conversion to AT I is prevented, which in turn prevents the conversion of AT I to AT II. This prevents arterial vasoconstriction by AT II and inhibits the production of aldosterone by AT II. As aldosterone causes re-uptake of sodium and water and eventually an increase in extracellular volume, aliskiren is able to prevent the effects that contribute to an increase in blood pressure. [from NCI]

MedGen UID:
362701
Concept ID:
C1879678
Organic Chemical; Pharmacologic Substance
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