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Items: 11

1.

Barrett esophagus

Barrett esophagus, or Barrett metaplasia, describes the phenotypic change of normal esophageal squamous epithelium to a columnar and intestinal-type epithelium. This metaplastic change is important because patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett metaplasia is gastroesophageal reflux (GER; 109350). The retrograde movement of acid and bile salts from the stomach into the esophagus in this disease causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes (summary by Wong et al., 2005). [from OMIM]

MedGen UID:
2551
Concept ID:
C0004763
Disease or Syndrome
2.

Barrett esophagus

An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system. [from HPO]

MedGen UID:
506488
Concept ID:
CN117473
Finding
3.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus). [from HPO]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
4.

Adenocarcinoma

A malignant neoplasm arising from glandular cells. [from NCI]

MedGen UID:
122
Concept ID:
C0001418
Neoplastic Process
5.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
6.

Squamous cell carcinoma

The presence of squamous cell carcinoma of the skin. [from HPO]

MedGen UID:
505376
Concept ID:
CN002585
Finding
7.

Carcinoma, Squamous Cell

The presence of squamous cell carcinoma of the skin. [from HPO]

MedGen UID:
2874
Concept ID:
C0007137
Neoplastic Process
8.

Abnormality of the digestive system

Congenital structural abnormalities of the DIGESTIVE SYSTEM. [from MeSH]

MedGen UID:
78584
Concept ID:
C0266015
Congenital Abnormality
9.

Abnormality of the gastrointestinal tract

When you eat, your body breaks food down to a form it can use to build and nourish cells and provide energy. This process is called digestion. . Your digestive system is a series of hollow organs joined in a long, twisting tube. It runs from your mouth to your anus and includes your esophagus, stomach, and small and large intestines. Your liver, gallbladder and pancreas are also involved. They produce juices to help digestion. . There are many types of digestive disorders. The symptoms vary widely depending on the problem. In general, you should see your doctor if you have . -Blood in your stool. -Changes in bowel habits. -Severe abdominal pain. -Unintentional weight loss. -Heartburn not relieved by antacids. NIH: National Institute of Diabetes and Digestive and Kidney Diseases .  [from MedlinePlus]

MedGen UID:
3828
Concept ID:
C0012242
Disease or Syndrome
10.

Adenocarcinoma of the intestines

A malignant epithelial tumor with a glandular organization that originates in the intestines. [from HPO]

MedGen UID:
909268
Concept ID:
C4280683
Neoplastic Process
11.

Barrett esophagus/esophageal adenocarcinoma

MedGen UID:
478704
Concept ID:
C3277074
Finding; Gene or Genome
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