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Items: 1 to 20 of 23

1.

Malignant tumor of prostate

MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
2.

Prostate cancer

MedGen UID:
506673
Concept ID:
CN167851
Finding
3.

Cancer Progression

A pathologic process in which alterations at the molecular level result in a more aggressive cytologic and phenotypic profile and clinical course of a malignant neoplasm. [from NCI]

MedGen UID:
364930
Concept ID:
C1947901
Pathologic Function
4.

Hyperplasia of prostate

Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. [from MeSH]

MedGen UID:
422472
Concept ID:
C2937421
Disease or Syndrome
5.

Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005). [from OMIM]

MedGen UID:
312369
Concept ID:
C1704272
Neoplastic Process
6.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
7.

Hyperplasia

An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement. [from NCI]

MedGen UID:
43784
Concept ID:
C0020507
Pathologic Function
8.

Benign prostatic hyperplasia

MedGen UID:
506248
Concept ID:
CN007662
Finding
9.

Invasion

The movement of one cell type into an area normally occupied by a different cell type. [from NCI]

MedGen UID:
397081
Concept ID:
C2699153
Pathologic Function
10.

AKT Signaling Pathway

Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activate the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes. (This definition may be outdated - see the DesignNote.) [from NCI_BioC]

MedGen UID:
271894
Concept ID:
C1515844
Molecular Function
11.

Ameliorated by

An ameliorating factor is defined as an external factor that leads to the manifestation of a sign or symptom in a person improving or becoming more bearable. [from HPO]

MedGen UID:
83049
Concept ID:
C0332161
Qualitative Concept
12.

Metastasis

The spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor. [from NCI]

MedGen UID:
45032
Concept ID:
C0027627
Neoplastic Process
13.

Signaling Pathway

An elaboration of the known or inferred interactions involved in a signal transduction pathway. [from NCI]

MedGen UID:
39530
Concept ID:
C0086982
Molecular Function
14.

Male Urogenital Diseases

Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE). [from MeSH]

MedGen UID:
318601
Concept ID:
C1720894
Disease or Syndrome
15.

Course of illness

The worsening of a disease over time. [from NCI]

MedGen UID:
116631
Concept ID:
C0242656
Pathologic Function
16.

Male Reproductive System Neoplasm

A benign, borderline, or malignant neoplasm that affects the male reproductive system. Representative examples include benign prostate phyllodes tumor, benign testicular Sertoli cell tumor, prostatic intraepithelial neoplasia, prostate carcinoma, testicular seminoma, and testicular embryonal carcinoma. [from NCI]

MedGen UID:
42196
Concept ID:
C0017417
Neoplastic Process
17.

Disorder of male genital organ

Pathological processes involving the male reproductive tract (GENITALIA, MALE). [from MeSH]

MedGen UID:
42195
Concept ID:
C0017412
Disease or Syndrome
18.

Genitourinary neoplasm

MedGen UID:
22583
Concept ID:
C0042065
Neoplastic Process
19.

Prostatic Neoplasms

MedGen UID:
18697
Concept ID:
C0033578
Neoplastic Process
20.

UPREG

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
12003
Concept ID:
C0041904
Molecular Function
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