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Valerian root extract

MedGen UID:
167051
Concept ID:
C0795674
Organic Chemical; Pharmacologic Substance
Synonyms: Valerian; Valerian extract; Valerian preparation; Valerian Root; Valeriana Officinalis Extract
SNOMED CT: Valerian extract (412266000); Valerian preparation (412268004); Valerian (412266000); Valerian root extract (427339006)
 

Definition

An herbal extract isolated from the root of the plant Valeriana officinalis with sedative and anxiolytic activities. Valeriana officinalis extract contains four distinct classes of phytochemical constituents: volatile oils; sesquiterpenoids, including valerenic acid and its hydroxyl and acetoxyl derivative; valepotriates; and volatile pyridine alkaloids. Although the exact mechanism of action has not been established, the sesquiterpenoids in Valeriana officinalis extract, particularly valerenic acid, appear to account for its sedative and anxiolytic effects. Valerenic acid is both a subtype-selective GABA-A receptor agonist and a 5HT-5A receptor partial agonist. The sedative-hypnotic benzodiazepines are GABA-A receptor agonists. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVValerian root extract

Recent clinical studies

Etiology

Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P
Psychopharmacology (Berl) 2015 Mar;232(5):843-50. Epub 2014 Aug 31 doi: 10.1007/s00213-014-3716-x. PMID: 25173770
Gromball J, Beschorner F, Wantzen C, Paulsen U, Burkart M
Phytomedicine 2014 Jul-Aug;21(8-9):1098-103. Epub 2014 May 15 doi: 10.1016/j.phymed.2014.04.004. PMID: 24837472

Diagnosis

Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P
Psychopharmacology (Berl) 2015 Mar;232(5):843-50. Epub 2014 Aug 31 doi: 10.1007/s00213-014-3716-x. PMID: 25173770

Therapy

Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P
Psychopharmacology (Berl) 2015 Mar;232(5):843-50. Epub 2014 Aug 31 doi: 10.1007/s00213-014-3716-x. PMID: 25173770
Gromball J, Beschorner F, Wantzen C, Paulsen U, Burkart M
Phytomedicine 2014 Jul-Aug;21(8-9):1098-103. Epub 2014 May 15 doi: 10.1016/j.phymed.2014.04.004. PMID: 24837472
Kuhlmann J, Berger W, Podzuweit H, Schmidt U
Pharmacopsychiatry 1999 Nov;32(6):235-41. doi: 10.1055/s-2007-991100. PMID: 10599933

Clinical prediction guides

Hassani S, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P
Psychopharmacology (Berl) 2015 Mar;232(5):843-50. Epub 2014 Aug 31 doi: 10.1007/s00213-014-3716-x. PMID: 25173770
Gromball J, Beschorner F, Wantzen C, Paulsen U, Burkart M
Phytomedicine 2014 Jul-Aug;21(8-9):1098-103. Epub 2014 May 15 doi: 10.1016/j.phymed.2014.04.004. PMID: 24837472

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