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Pancreatic dysplasia

MedGen UID:
468983
Concept ID:
C1301034
Neoplastic Process
Synonyms: Pancreatic Dysplasia; Pancreatic intraepithelial neoplasia; Pancreatic Intraepithelial Neoplasia; Pancreatic intraepithelial neoplasia (PanIN); PanIN
SNOMED CT: Pancreatic intraepithelial neoplasia (PanIN) (396871009); Pancreatic intraepithelial neoplasia (396871009)
 

Definition

A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts. It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter. [from NCI]

Recent clinical studies

Etiology

Kapur RP, Cole B, Zhang M, Lin J, Fligner CL
Pediatr Dev Pathol 2013 May-Jun;16(3):191-200. Epub 2013 Feb 25 doi: 10.2350/12-12-1281-OA.1. PMID: 23438674
Fiskerstrand T, Houge G, Sund S, Scheie D, Leh S, Boman H, Knappskog PM
J Mol Diagn 2010 Jan;12(1):125-31. Epub 2009 Dec 10 doi: 10.2353/jmoldx.2010.090033. PMID: 20007846Free PMC Article
Lee JG, Urayama S
Gastrointest Endosc 2000 Jul;52(1):138-40. PMID: 11012299
Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB
Ann Intern Med 1999 Aug 17;131(4):247-55. PMID: 10454945
Bernstein J, Chandra M, Creswell J, Kahn E, Malouf NN, McVicar M, Weinberg AG, Wybel RE
Am J Med Genet 1987 Feb;26(2):391-403. doi: 10.1002/ajmg.1320260218. PMID: 3812591

Diagnosis

Witters I, Devriendt K, Spinnewijn D, Moerman P, Van Assche FA, Fryns JP
Am J Med Genet 2002 Jan 22;107(3):233-6. PMID: 11807905
Lee JG, Urayama S
Gastrointest Endosc 2000 Jul;52(1):138-40. PMID: 11012299
Balci S, Bostanoğlu S, Altinok G, Ozaltin F
Am J Med Genet 2000 Jan 31;90(3):185-7. PMID: 10678653
Bae S, Kurtz RC
Lancet 2000 Jan 8;355(9198):85-6. doi: 10.1016/S0140-6736(99)00354-2. PMID: 10675163
Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB
Ann Intern Med 1999 Aug 17;131(4):247-55. PMID: 10454945

Therapy

Lee JG, Urayama S
Gastrointest Endosc 2000 Jul;52(1):138-40. PMID: 11012299
Attia N, Zahrani A, Saif R, Kattan HA, Sakati N, Al Ashwal A, Tamborlane WV
Acta Paediatr 1998 Jan;87(1):95-7. PMID: 9510456

Prognosis

Charpentier KP, Brentnall TA, Bronner MP, Byrd D, Marsh C
Clin Transplant 2004 Feb;18(1):105-7. PMID: 15108779
Witters I, Devriendt K, Spinnewijn D, Moerman P, Van Assche FA, Fryns JP
Am J Med Genet 2002 Jan 22;107(3):233-6. PMID: 11807905
Lee JG, Urayama S
Gastrointest Endosc 2000 Jul;52(1):138-40. PMID: 11012299
Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB
Ann Intern Med 1999 Aug 17;131(4):247-55. PMID: 10454945
Torra R, Alós L, Ramos J, Estivill X
J Med Genet 1996 May;33(5):409-12. PMID: 8733053Free PMC Article

Clinical prediction guides

Rajagopalan R, Grochowski CM, Gilbert MA, Falsey AM, Coleman K, Romero R, Loomes KM, Piccoli DA, Devoto M, Spinner NB
Am J Med Genet A 2016 Mar;170(3):750-3. Epub 2015 Dec 24 doi: 10.1002/ajmg.a.37512. PMID: 26697755
Frank V, Habbig S, Bartram MP, Eisenberger T, Veenstra-Knol HE, Decker C, Boorsma RA, Göbel H, Nürnberg G, Griessmann A, Franke M, Borgal L, Kohli P, Völker LA, Dötsch J, Nürnberg P, Benzing T, Bolz HJ, Johnson C, Gerkes EH, Schermer B, Bergmann C
Hum Mol Genet 2013 Jun 1;22(11):2177-85. Epub 2013 Feb 14 doi: 10.1093/hmg/ddt070. PMID: 23418306
Fiskerstrand T, Houge G, Sund S, Scheie D, Leh S, Boman H, Knappskog PM
J Mol Diagn 2010 Jan;12(1):125-31. Epub 2009 Dec 10 doi: 10.2353/jmoldx.2010.090033. PMID: 20007846Free PMC Article
Witters I, Devriendt K, Spinnewijn D, Moerman P, Van Assche FA, Fryns JP
Am J Med Genet 2002 Jan 22;107(3):233-6. PMID: 11807905
Brentnall TA, Bronner MP, Byrd DR, Haggitt RC, Kimmey MB
Ann Intern Med 1999 Aug 17;131(4):247-55. PMID: 10454945

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