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Items: 5

1.

lumiracoxib

MedGen UID:
222111
Concept ID:
C1176415
Organic Chemical; Pharmacologic Substance
2.

Osteoarthritis susceptibility 1

Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading to significant disability and joint replacement. Osteoarthritis exhibits a clear predilection for specific joints; it appears most commonly in the hip and knee joints and lumbar and cervical spine, as well as in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints of the hand; however, patients with osteoarthritis may have 1, a few, or all of these sites affected (Stefansson et al., 2003). According to a conservative estimate, greater than 70% of the population of the United States at age 65 years is affected by the disease, reflecting its age dependence. Genetic Heterogeneity of Susceptibility to Osteoarthritis Susceptibility to osteoarthritis has been associated with variation in other genes: OS2 (140600) with variation in the MATN3 gene (602109) on chromosome 2p24; OS3 (607850) with variation in the ASPN gene (608135) on chromosome 9q22; and OS5 (612400) with variation in the GDF5 gene (601146) on chromosome 20q11. Other susceptibility loci for osteoarthritis have been mapped to chromosomes 2q33 (OS4; 610839) and 3p24 (OS6; 612401). [from OMIM]

MedGen UID:
45244
Concept ID:
C0029408
Disease or Syndrome
3.

Naproxen

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. [from MeSH]

MedGen UID:
45000
Concept ID:
C0027396
Organic Chemical; Pharmacologic Substance
4.

Ibuprofen

A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. [from MeSH]

MedGen UID:
9394
Concept ID:
C0020740
Organic Chemical; Pharmacologic Substance
5.

Osteoarthritis

MedGen UID:
505348
Concept ID:
CN002503
Finding
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