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Items: 1 to 20 of 27

1.

4-Bromoflavone

MedGen UID:
158519
Concept ID:
C0763460
Organic Chemical; Pharmacologic Substance
2.

Carcinogenesis

A pathological process in which normal cells are transformed into malignant cancer cells within a primary tumor. [from NCI]

MedGen UID:
154544
Concept ID:
C0596263
Neoplastic Process
3.

Mutagenesis

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS. [from MeSH]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
4.

Lymphoma

A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [from HPO]

MedGen UID:
44223
Concept ID:
C0024299
Neoplastic Process
5.

Polyphenol

A large class of organic compounds having more than one PHENOL group. [from MeSH]

MedGen UID:
34867
Concept ID:
C0071649
Organic Chemical; Pharmacologic Substance
6.

Indole-3-Carbinol

A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone. [from NCI]

MedGen UID:
30431
Concept ID:
C0063491
Organic Chemical; Pharmacologic Substance
7.

Geraniol

A terpene with two isoprene units head to tail with hydroxyl group attached to the head methyl group. The chemical structure is CC(=CCC\C(=C\CO)\C)C. [from NCI_CRCH]

MedGen UID:
29589
Concept ID:
C0061223
Organic Chemical; Pharmacologic Substance
8.

carbazole

MedGen UID:
27752
Concept ID:
C0054658
Organic Chemical; Pharmacologic Substance
9.

1,2-Dithiole-3-Thione

MedGen UID:
22025
Concept ID:
C0043854
Organic Chemical; Pharmacologic Substance
10.

Acetic acid

A synthetic carboxylic acid with antibacterial and antifungal properties. Although its mechanism of action is not fully known, undissociated acetic acid may enhance lipid solubility allowing increased fatty acid accumulation on the cell membrane or in other cell wall structures. Acetic acid, as a weak acid, can inhibit carbohydrate metabolism resulting in subsequent death of the organism. [from NCI]

MedGen UID:
7835
Concept ID:
C0000983
Indicator, Reagent, or Diagnostic Aid; Organic Chemical; Pharmacologic Substance
11.

Metabolic induction

The conversion of an exogenous substance by a biological system resulting in the production on an active metabolite. [from MeSH]

MedGen UID:
7561
Concept ID:
C0025513
Molecular Function
12.

Indole

A class of bicyclic organic compounds composed of a phenyl ring attached to a nitrogen-containing pyrrole ring. The chemical structure is C1(NC=C2)=C2C=CC=C1. [from NCI_CRCH]

MedGen UID:
5785
Concept ID:
C0021236
Organic Chemical; Pharmacologic Substance
13.

Farnesol

A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) [from MeSH]

MedGen UID:
4656
Concept ID:
C0015637
Organic Chemical; Pharmacologic Substance
14.

Chromosomal anomaly

Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. [from MeSH]

MedGen UID:
954
Concept ID:
C0008625
Cell or Molecular Dysfunction
15.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
16.

Micronucleus

A toxicology screening result where proliferating cells that are exposed to a genotoxic chemical produce some daughter cells containing cytoplasmic bodies that are comprised of chromosomes or chromosome fragments, which were not sorted properly during mitosis or meiosis, and are bounded by a nuclear membrane. [from NCI]

MedGen UID:
507946
Concept ID:
C0026004
Finding
17.

Lymphoma

A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells. [from HPO]

MedGen UID:
505322
Concept ID:
CN002422
Finding
18.

Bowman-Birk Inhibitor Concentrate

An extract of soybeans enriched in Bowman-Birk inhibitor (BBI), a soybean-derived, 71-amino acid, polypeptide and serine protease inhibitor with potential chemopreventive activity. Bowman-Birk inhibitor contains distinct inhibitory sites for trypsin and chymotrypsin. Although the exact mechanism by which BBI suppresses carcinogenesis is unknown, its antiproliferative activity appears to be linked to the chymotrypsin inhibitory region. [from NCI]

MedGen UID:
310507
Concept ID:
C1706991
Amino Acid, Peptide, or Protein; Pharmacologic Substance
19.

Mouse Lymphoma

MedGen UID:
279378
Concept ID:
C1522021
Neoplastic Process
20.

Methylselenocysteine

A naturally occurring organoselenium compound found in many plants, including garlic, onions, and broccoli, with potential antioxidant and chemopreventive activities. Se-Methyl-seleno-L-cysteine (MSC) is an amino acid analogue of cysteine in which a methylselenium moiety replaces the sulphur atom of cysteine. This agent acts as an antioxidant when incorporated into glutathione peroxidase and has been shown to exhibit potent chemopreventive activity in animal models. [from NCI]

MedGen UID:
78162
Concept ID:
C0074299
Organic Chemical; Pharmacologic Substance
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