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Items: 5

1.

Tolvaptan

An orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia. Upon oral administration, tolvaptan selectively and competitively binds to and blocks the V2 receptor located in the walls of the vasculature and luminal membranes of renal collecting ducts, thereby preventing the binding of vasopressin to the V2 receptor. This prevents water absorption in the kidneys and increases the excretion of electrolyte-free water via the kidneys. This reduces intravascular volume and increases serum sodium concentrations and osmolality. [from NCI]

MedGen UID:
222094
Concept ID:
C1176308
Organic Chemical; Pharmacologic Substance
2.

Heart failure

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. [from MeSH]

MedGen UID:
6749
Concept ID:
C0018801
Disease or Syndrome
3.

Heart Failure

MedGen UID:
880986
Concept ID:
CN236639
Disease or Syndrome
4.

Congestive heart failure

Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales. [from NCI]

MedGen UID:
9169
Concept ID:
C0018802
Disease or Syndrome
5.

Increased thirst

MedGen UID:
537050
Concept ID:
C0241379
Sign or Symptom
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