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Items: 8

1.

Venous stasis syndrome

A condition caused by one or more episodes of DEEP VEIN THROMBOSIS, usually the blood clots are lodged in the legs. Clinical features include EDEMA; PAIN; aching; heaviness; and MUSCLE CRAMP in the leg. When severe leg swelling leads to skin breakdown, it is called venous STASIS ULCER. [from MeSH]

MedGen UID:
82924
Concept ID:
C0277919
Pathologic Function
2.

Venous thrombosis

Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow. [from HPO]

MedGen UID:
22631
Concept ID:
C0042487
Pathologic Function
3.

Thrombosis

Formation and development of a thrombus or blood clot in the blood vessel. [from MeSH]

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
4.

High risk of

The potential future harm that may arise from some present action or attribute or condition is almost certain. [from NCI]

MedGen UID:
568174
Concept ID:
C0332167
Finding
5.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele in F2 never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders (e.g., antiphospholipid antibodies). Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GTR]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
6.

Deep venous thrombosis

A blood clot in a deep vein, predominantly in the lower extremity, but may include the pelvis or upper extremity.(NICHD) [from NCI]

MedGen UID:
57448
Concept ID:
C0149871
Disease or Syndrome
7.

Postthrombotic syndrome

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous VARICOSE VEINS are usually present. Leg pain may occur after long period of standing. [from MeSH]

MedGen UID:
46043
Concept ID:
C0032807
Disease or Syndrome
8.

Thrombolytic agent

Any agent capable of dissolving an existing blood clot in order to reperfuse the blocked blood vessel. [from NCI]

MedGen UID:
42013
Concept ID:
C0016018
Pharmacologic Substance
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