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Venlafaxine

MedGen UID:
36191
Concept ID:
C0078569
Organic Chemical; Pharmacologic Substance
Drug response:
Venlafaxine response
MedGen UID:
450500
Concept ID:
CN078028
Sign or Symptom
Venlafaxine is an antidepressant used in the treatment of major depressive order, anxiety, and panic disorders. Venlafaxine belongs to the drug class of serotonin and norepinephrine reuptake inhibitors (SNRIs). The CYP2D6 enzyme metabolizes a quarter of all prescribed drugs, including venlafaxine. This enzyme converts venlafaxine to the active metabolite, O-desmethylvenlafaxine (ODV). Individuals who carry two inactive copies of CYP2D6 ("poor metabolizers") may have decreased capacity to metabolize venlafaxine, resulting in less active metabolites in their system. In contrast, individuals who carry more than two copies of functional CYP2D6 alleles ("ultrarapid metabolizers") may have an enhanced capacity to metabolize venlafaxine, resulting in more increased active metabolites in their system. The FDA states that because the total exposure of venlafaxine and ODV is similar in poor and extensive (normal) metabolizers, there is no need for different venlafaxine dosing regimens for these individuals. However, the Dutch Pharmacogenetics Working Group recommends that both poor and intermediate metabolizer genotypes should be treated with an alternative drug, or lower doses of venlafaxine based on clinical response and drug levels. For ultrarapid metabolizer genotypes, they recommend that either the dose of venlafaxine be increased up to 150% of the normal dose, or an alternative drug used.
SNOMED CT: Venlafaxine (372490001); Venlafaxine (108432009)
 

Definition

A synthetic phenethylamine bicyclic derivative with antidepressant activity. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak dopamine reuptake inhibitors. This agent may reduce hormone-related vasomotor symptoms. (NCI04) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVenlafaxine

Recent clinical studies

Etiology

Lin HW, Simonavice CA, Lu CR, Lin WL, Wu PL, Chou CY, Liao CH, Lane HY
BMC Health Serv Res 2017 Apr 13;17(1):272. doi: 10.1186/s12913-017-2195-2. PMID: 28407764Free PMC Article
Ozbey G, Celikel FC, Cumurcu BE, Kan D, Yucel B, Hasbek E, Percin F, Guzey IC, Uluoglu C
Nord J Psychiatry 2017 Apr;71(3):230-237. Epub 2017 Jan 12 doi: 10.1080/08039488.2016.1268203. PMID: 28079463
Holland J, Brown R
Eur J Paediatr Neurol 2017 Mar;21(2):264-268. Epub 2016 Nov 25 doi: 10.1016/j.ejpn.2016.11.003. PMID: 27931774
Thase M, Asami Y, Wajsbrot D, Dorries K, Boucher M, Pappadopulos E
Curr Med Res Opin 2017 Feb;33(2):317-326. Epub 2016 Nov 28 doi: 10.1080/03007995.2016.1255185. PMID: 27794623
Sonne C, Carlsson J, Bech P, Elklit A, Mortensen EL
BMC Psychiatry 2016 Nov 8;16(1):383. doi: 10.1186/s12888-016-1081-5. PMID: 27825327Free PMC Article

Diagnosis

Li X, Zhu L, Su Y, Fang S
PLoS One 2017;12(10):e0185865. Epub 2017 Oct 5 doi: 10.1371/journal.pone.0185865. PMID: 28982121Free PMC Article
Ozbey G, Celikel FC, Cumurcu BE, Kan D, Yucel B, Hasbek E, Percin F, Guzey IC, Uluoglu C
Nord J Psychiatry 2017 Apr;71(3):230-237. Epub 2017 Jan 12 doi: 10.1080/08039488.2016.1268203. PMID: 28079463
Holland J, Brown R
Eur J Paediatr Neurol 2017 Mar;21(2):264-268. Epub 2016 Nov 25 doi: 10.1016/j.ejpn.2016.11.003. PMID: 27931774
Kus T, Aktas G, Alpak G, Kalender ME, Sevinc A, Kul S, Temizer M, Camci C
Support Care Cancer 2016 May;24(5):2085-2091. Epub 2015 Nov 7 doi: 10.1007/s00520-015-3009-x. PMID: 26546457
Doroudgar S, Perry PJ, Lackey GD, Veselova NG, Chuang HM, Albertson TE
Hum Exp Toxicol 2016 Jul;35(7):767-74. Epub 2015 Sep 8 doi: 10.1177/0960327115604202. PMID: 26351291

Therapy

Lin HW, Simonavice CA, Lu CR, Lin WL, Wu PL, Chou CY, Liao CH, Lane HY
BMC Health Serv Res 2017 Apr 13;17(1):272. doi: 10.1186/s12913-017-2195-2. PMID: 28407764Free PMC Article
Ozbey G, Celikel FC, Cumurcu BE, Kan D, Yucel B, Hasbek E, Percin F, Guzey IC, Uluoglu C
Nord J Psychiatry 2017 Apr;71(3):230-237. Epub 2017 Jan 12 doi: 10.1080/08039488.2016.1268203. PMID: 28079463
Marshe VS, Maciukiewicz M, Rej S, Tiwari AK, Sibille E, Blumberger DM, Karp JF, Lenze EJ, Reynolds CF 3rd, Kennedy JL, Mulsant BH, Müller DJ
Am J Psychiatry 2017 May 1;174(5):468-475. Epub 2017 Jan 10 doi: 10.1176/appi.ajp.2016.16050617. PMID: 28068779
Holland J, Brown R
Eur J Paediatr Neurol 2017 Mar;21(2):264-268. Epub 2016 Nov 25 doi: 10.1016/j.ejpn.2016.11.003. PMID: 27931774
Thase M, Asami Y, Wajsbrot D, Dorries K, Boucher M, Pappadopulos E
Curr Med Res Opin 2017 Feb;33(2):317-326. Epub 2016 Nov 28 doi: 10.1080/03007995.2016.1255185. PMID: 27794623

Prognosis

Marshe VS, Maciukiewicz M, Rej S, Tiwari AK, Sibille E, Blumberger DM, Karp JF, Lenze EJ, Reynolds CF 3rd, Kennedy JL, Mulsant BH, Müller DJ
Am J Psychiatry 2017 May 1;174(5):468-475. Epub 2017 Jan 10 doi: 10.1176/appi.ajp.2016.16050617. PMID: 28068779
Thase M, Asami Y, Wajsbrot D, Dorries K, Boucher M, Pappadopulos E
Curr Med Res Opin 2017 Feb;33(2):317-326. Epub 2016 Nov 28 doi: 10.1080/03007995.2016.1255185. PMID: 27794623
Lin HP, Sun D, Zhang X, Wen H
J Pharm Sci 2016 Oct;105(10):3088-3096. Epub 2016 Jul 19 doi: 10.1016/j.xphs.2016.06.015. PMID: 27449228
Stoetzer C, Papenberg B, Doll T, Völker M, Heineke J, Stoetzer M, Wegner F, Leffler A
Eur J Pharmacol 2016 Jul 15;783:1-10. Epub 2016 Apr 27 doi: 10.1016/j.ejphar.2016.04.051. PMID: 27130441
Yeh YW, Chen CJ, Jang FL, Kuo SC, Chen CY, Liang CS, Ho PS, Yen CH, Shyu JF, Wan FJ, Lu RB, Huang SY
J Psychiatr Res 2015 Feb;61:33-9. Epub 2014 Dec 4 doi: 10.1016/j.jpsychires.2014.11.017. PMID: 25512257

Clinical prediction guides

Ozbey G, Celikel FC, Cumurcu BE, Kan D, Yucel B, Hasbek E, Percin F, Guzey IC, Uluoglu C
Nord J Psychiatry 2017 Apr;71(3):230-237. Epub 2017 Jan 12 doi: 10.1080/08039488.2016.1268203. PMID: 28079463
Marshe VS, Maciukiewicz M, Rej S, Tiwari AK, Sibille E, Blumberger DM, Karp JF, Lenze EJ, Reynolds CF 3rd, Kennedy JL, Mulsant BH, Müller DJ
Am J Psychiatry 2017 May 1;174(5):468-475. Epub 2017 Jan 10 doi: 10.1176/appi.ajp.2016.16050617. PMID: 28068779
Holland J, Brown R
Eur J Paediatr Neurol 2017 Mar;21(2):264-268. Epub 2016 Nov 25 doi: 10.1016/j.ejpn.2016.11.003. PMID: 27931774
Thase M, Asami Y, Wajsbrot D, Dorries K, Boucher M, Pappadopulos E
Curr Med Res Opin 2017 Feb;33(2):317-326. Epub 2016 Nov 28 doi: 10.1080/03007995.2016.1255185. PMID: 27794623
Sonne C, Carlsson J, Bech P, Elklit A, Mortensen EL
BMC Psychiatry 2016 Nov 8;16(1):383. doi: 10.1186/s12888-016-1081-5. PMID: 27825327Free PMC Article

Recent systematic reviews

Li X, Zhu L, Su Y, Fang S
PLoS One 2017;12(10):e0185865. Epub 2017 Oct 5 doi: 10.1371/journal.pone.0185865. PMID: 28982121Free PMC Article
Thase M, Asami Y, Wajsbrot D, Dorries K, Boucher M, Pappadopulos E
Curr Med Res Opin 2017 Feb;33(2):317-326. Epub 2016 Nov 28 doi: 10.1080/03007995.2016.1255185. PMID: 27794623
Lassen D, Ennis ZN, Damkier P
Basic Clin Pharmacol Toxicol 2016 Jan;118(1):32-6. Epub 2015 Nov 3 doi: 10.1111/bcpt.12497. PMID: 26435496
Doroudgar S, Perry PJ, Lackey GD, Veselova NG, Chuang HM, Albertson TE
Hum Exp Toxicol 2016 Jul;35(7):767-74. Epub 2015 Sep 8 doi: 10.1177/0960327115604202. PMID: 26351291
VanderWeide LA, Smith SM, Trinkley KE
J Clin Pharm Ther 2015 Feb;40(1):1-6. Epub 2014 Oct 8 doi: 10.1111/jcpt.12216. PMID: 25294655

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