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Leiomyoma

MedGen UID:
9710
•Concept ID:
C0023267
•
Neoplastic Process
Synonyms: Fibroid; Fibroid Tumor; Fibroid Tumors; Fibroids; Fibromyoma; Fibromyomas; Leiomyomas; Tumor, Fibroid; Tumors, Fibroid
SNOMED CT: Fibromyoma (1162890002); Leiomyofibroma (1162890002); Plexiform leiomyoma (1162890002); Fibroleiomyoma (1162890002); Fibroid (1162890002); Leiomyoma (1162890002); Soft tissue tumor of smooth muscle differentiation (1187125003); Leiomyomatous neoplasm (1187125003)
 
Monarch Initiative: MONDO:0001572

Definition

A well-circumscribed benign smooth muscle neoplasm characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeiomyoma

Professional guidelines

PubMed

Evaluation and management of abnormal uterine bleeding.
Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128

Recent clinical studies

Etiology

Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study.
Qu Y, Chen L, Guo S, Liu Y, Wu H
Front Endocrinol (Lausanne) 2023;14:1133260. Epub 2023 Jul 27 doi: 10.3389/fendo.2023.1133260. PMID: 37576957Free PMC Article
Epidemiology and Risk Factors of Uterine Fibroids.
Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:3-11. Epub 2017 Oct 1 doi: 10.1016/j.bpobgyn.2017.09.004. PMID: 29054502
The effect of uterine leiomyoma on the risk of malpresentation and cesarean: a meta-analysis.
Jenabi E, Khazaei S
J Matern Fetal Neonatal Med 2018 Jan;31(1):87-92. Epub 2017 Jan 17 doi: 10.1080/14767058.2016.1275553. PMID: 28027686
Recent Advances in Uterine Fibroid Etiology.
McWilliams MM, Chennathukuzhi VM
Semin Reprod Med 2017 Mar;35(2):181-189. Epub 2017 Mar 9 doi: 10.1055/s-0037-1599090. PMID: 28278535Free PMC Article
The association between uterine leiomyoma and placenta abruption: A meta-analysis.
Jenabi E, Ebrahimzadeh Zagami S
J Matern Fetal Neonatal Med 2017 Nov;30(22):2742-2746. Epub 2016 Nov 29 doi: 10.1080/14767058.2016.1261401. PMID: 27844480

Diagnosis

Intraparenchymal breast leiomyoma and atypical leiomyoma.
Long M, Hu XL, Zhao G, Liu Y, Hu T
BMC Womens Health 2022 Apr 14;22(1):119. doi: 10.1186/s12905-022-01700-6. PMID: 35421983Free PMC Article
Leiomyoma with nuclear atypia: Rare diseases that present a common diagnostic problem.
Wei JJ
Semin Diagn Pathol 2022 May;39(3):187-200. Epub 2022 Feb 2 doi: 10.1053/j.semdp.2022.01.006. PMID: 35144823Free PMC Article
Fibroids: diagnosis and management.
Lumsden MA, Hamoodi I, Gupta J, Hickey M
BMJ 2015 Oct 13;351:h4887. doi: 10.1136/bmj.h4887. PMID: 26463991
Review of Leiomyoma Variants.
Arleo EK, Schwartz PE, Hui P, McCarthy S
AJR Am J Roentgenol 2015 Oct;205(4):912-21. doi: 10.2214/AJR.14.13946. PMID: 26397344
Paraurethral leiomyoma.
Pastor Navarro H, Martínez Ruiz J, Martínez Sanchíz C, Perán Teruel M, Segura Martín M, Pastor Guzman JM, Virseda Rodríguez J
Arch Esp Urol 2013 Oct;66(8):820-3. PMID: 24136487

Therapy

Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Uterine-Artery Embolization or Myomectomy for Uterine Fibroids.
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Limbo.
Schorge JO
Obstet Gynecol 2018 Jun;131(6):959-960. doi: 10.1097/AOG.0000000000002610. PMID: 29688918
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Uterine fibroid management: from the present to the future.
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article

Prognosis

Depot Medroxyprogesterone Acetate Use and the Development and Progression of Uterine Leiomyoma.
Harmon QE, Patchel SA, Zhao S, Umbach DM, Cooper TE, Baird DD
Obstet Gynecol 2022 May 1;139(5):797-807. Epub 2022 Apr 5 doi: 10.1097/AOG.0000000000004745. PMID: 35576339Free PMC Article
Evaluation and Management of Abnormal Uterine Bleeding.
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Disparities in Fibroid Incidence, Prognosis, and Management.
Laughlin-Tommaso SK, Jacoby VL, Myers ER
Obstet Gynecol Clin North Am 2017 Mar;44(1):81-94. doi: 10.1016/j.ogc.2016.11.007. PMID: 28160895
Epidemiology of myomas.
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article
Gastrointestinal stromal tumors.
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170

Clinical prediction guides

Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Uterine-Artery Embolization or Myomectomy for Uterine Fibroids.
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
The effect of uterine leiomyoma on the risk of malpresentation and cesarean: a meta-analysis.
Jenabi E, Khazaei S
J Matern Fetal Neonatal Med 2018 Jan;31(1):87-92. Epub 2017 Jan 17 doi: 10.1080/14767058.2016.1275553. PMID: 28027686
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Epidemiology of myomas.
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article

Recent systematic reviews

Reproductive and Obstetric Outcomes after UAE, HIFU, and TFA of Uterine Fibroids: Systematic Review and Meta-Analysis.
Akhatova A, Aimagambetova G, Bapayeva G, Laganà AS, Chiantera V, Oppelt P, Sarria-Santamera A, Terzic M
Int J Environ Res Public Health 2023 Mar 2;20(5) doi: 10.3390/ijerph20054480. PMID: 36901489Free PMC Article
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Fibroids and natural fertility: a systematic review and meta-analysis.
Somigliana E, Reschini M, Bonanni V, Busnelli A, Li Piani L, Vercellini P
Reprod Biomed Online 2021 Jul;43(1):100-110. Epub 2021 Mar 23 doi: 10.1016/j.rbmo.2021.03.013. PMID: 33903032
Epidemiology of uterine fibroids: a systematic review.
Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R
BJOG 2017 Sep;124(10):1501-1512. Epub 2017 May 13 doi: 10.1111/1471-0528.14640. PMID: 28296146
Fibroids and infertility: an updated systematic review of the evidence.
Pritts EA, Parker WH, Olive DL
Fertil Steril 2009 Apr;91(4):1215-23. Epub 2008 Mar 12 doi: 10.1016/j.fertnstert.2008.01.051. PMID: 18339376

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