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1.

Angiotensin II

An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS. [from MeSH]

MedGen UID:
1932
Concept ID:
C0003009
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
2.

Stiffness

MedGen UID:
98101
Concept ID:
C0427008
Sign or Symptom
3.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
4.

Angiotensin

Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized. [from MeSH]

MedGen UID:
1548
Concept ID:
C0003018
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
5.

Aortic Stiffness

MedGen UID:
465250
Concept ID:
C3178782
Pathologic Function
6.

Perindopril

An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure. [from MeSH]

MedGen UID:
54447
Concept ID:
C0136123
Organic Chemical; Pharmacologic Substance
7.

Losartan

An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II. [from MeSH]

MedGen UID:
50933
Concept ID:
C0126174
Organic Chemical; Pharmacologic Substance
8.

Hypertension

Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart beats, it pumps blood into the arteries. Your blood pressure is highest when your heart beats, pumping the blood. This is called systolic pressure. When your heart is at rest, between beats, your blood pressure falls. This is called diastolic pressure. . Your blood pressure reading uses these two numbers. Usually the systolic number comes before or above the diastolic number. A reading of. -119/79 or lower is normal blood pressure. -140/90 or higher is high blood pressure. -Between 120 and 139 for the top number, or between 80 and 89 for the bottom number is called prehypertension. Prehypertension means you may end up with high blood pressure, unless you take steps to prevent it. High blood pressure usually has no symptoms, but it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. You can control high blood pressure through healthy lifestyle habits such as exercise and the DASH diet and taking medicines, if needed. . NIH: National Heart, Lung, and Blood Institute.  [from MedlinePlus]

MedGen UID:
6969
Concept ID:
C0020538
Disease or Syndrome
9.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
10.

Hypertension

A finding of increased blood pressure; not necessarily hypertensive disorder [from SNOMEDCT_US]

MedGen UID:
635666
Concept ID:
C0497247
Finding
11.

Pressure

MedGen UID:
632176
Concept ID:
C0460139
Finding
12.

Moderate

Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
525853
Concept ID:
C0205081
Qualitative Concept
13.

Mild

Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated. [from SNOMEDCT_US]

MedGen UID:
268697
Concept ID:
C1513302
Finding
14.

Angiotensin II Type 1 Receptor Blockers

Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS. [from MeSH]

MedGen UID:
304245
Concept ID:
C1449680
Pharmacologic Substance
15.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
16.

DuP-753

MedGen UID:
196008
Concept ID:
C0700620
Organic Chemical; Pharmacologic Substance
17.

Angiotensin Receptor Antagonists

Agents that antagonize ANGIOTENSIN RECEPTORS. Many drugs in this class specifically target the ANGIOTENSIN TYPE 1 RECEPTOR. [from MeSH]

MedGen UID:
163390
Concept ID:
C0815017
Pharmacologic Substance
18.

S-9490

MedGen UID:
156049
Concept ID:
C0752280
Organic Chemical; Pharmacologic Substance
19.

Perstarium

MedGen UID:
156048
Concept ID:
C0752279
Organic Chemical; Pharmacologic Substance
20.

Cozaar

MedGen UID:
108489
Concept ID:
C0591301
Organic Chemical; Pharmacologic Substance
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