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Items: 1 to 20 of 38

1.

Corticotropin releasing factor preparation

A hormone synthesized in the hypothalamus and regulates the secretion of adrenocorticotropic hormone (ACTH). [from NCI]

MedGen UID:
3632
Concept ID:
C0010132
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
2.

Corticotropin

Corticotropin (39 aa, ~5 kDa) is encoded by the human POMC gene. This protein plays a role in the stimulation of cortisol secretion by the adrenal gland. [from NCI]

MedGen UID:
896260
Concept ID:
C3818725
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
3.

Antidepressant

A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression. [from NCI]

MedGen UID:
1588
Concept ID:
C0003289
Pharmacologic Substance
4.

Selective serotonin re-uptake inhibitor

Any agent that increases the extracellular level of the neurotransmitter serotonin (5-HT) by inhibiting its reuptake into the presynaptic cell. Increased level in the synaptic cleft prolongs the action of 5-HT on the postsynaptic receptor. This type of agent is typically used as an antidepressant and in the treatment of anxiety disorders and some personality disorders. They are also typically effective and used in treating some cases of insomnia. [from NCI]

MedGen UID:
452467
Concept ID:
C0360105
Pharmacologic Substance
5.

Fluoxetine

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. [from MeSH]

MedGen UID:
42053
Concept ID:
C0016365
Organic Chemical; Pharmacologic Substance
6.

Anxiety

Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus. [from NCI]

MedGen UID:
1613
Concept ID:
C0003467
Finding; Finding
7.

Mal de debarquement syndrome

MedGen UID:
345629
Concept ID:
C1608983
Disease or Syndrome
8.

Anxiety

Human personality is shaped by genetic and environmental factors, and evidence suggests that the genetic component is highly complex, polygenic, and epistatic. Genetic factors are thought to contribute to 40 to 60% of trait variance. Molecular genetics has tried to identify specific genes for quantitative traits, called quantitative trait loci (QTLs). The QTL concept suggests that complex personality traits or dimensions are not attributable to single genes, but to multiple interacting genes (Reif and Lesch, 2003). Fullerton et al. (2003) stated that psychologists were in agreement that the wide variation in human personalities can be explained by a small number of personality factors, including neuroticism (a measure of emotional stability), which manifests at one extreme as anxiety, depression, moodiness, low self-esteem, and diffidence. They cited a number of studies that had described a relationship between high scores on measures of neuroticism and major depressive disorder. They also noted that theoretical studies had suggested that large samples of randomly ascertained sibs could be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. See also panic disorder (PAND1; 167870), which is a subtype of anxiety disorder. [from GTR]

MedGen UID:
335849
Concept ID:
C1842981
Mental or Behavioral Dysfunction
9.

Major depressive disorder

Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation. [from MeSH]

MedGen UID:
266123
Concept ID:
C1269683
Mental or Behavioral Dysfunction
10.

Pathogenesis

The pathologic, physiologic, or biochemical mechanism resulting in the development of a disease or morbid process. [from NCI]

MedGen UID:
195936
Concept ID:
C0699748
Pathologic Function
11.

Involutional paraphrenia

MedGen UID:
345506
Concept ID:
C1571983
Mental or Behavioral Dysfunction
12.

Sarafem

MedGen UID:
306390
Concept ID:
C1692877
Organic Chemical; Pharmacologic Substance
13.

Psychosis, Involutional

Severe mental disorder with onset in MIDDLE AGE, marked by withdrawal, abnormal affect, disturbed intellectual processes, and there may be regression. [from MeSH]

MedGen UID:
295683
Concept ID:
C1571984
Mental or Behavioral Dysfunction
14.

Membrane Transport Modulators

Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS. [from MeSH]

MedGen UID:
288786
Concept ID:
C1563710
Pharmacologic Substance
15.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
16.

Lilly-110140

MedGen UID:
154243
Concept ID:
C0543453
Organic Chemical; Pharmacologic Substance
17.

Diagnosis, Psychiatric

MedGen UID:
138165
Concept ID:
C0376338
Mental or Behavioral Dysfunction
18.

Genetic predisposition

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. [from MeSH]

MedGen UID:
137259
Concept ID:
C0314657
Organism Attribute
19.

Inhibitors, Serotonin Uptake

Compounds that specifically inhibit the reuptake of serotonin in the brain. [from MeSH]

MedGen UID:
102458
Concept ID:
C0162758
Pharmacologic Substance
20.

Neurotic Depression

A term used for any state of depression that is not psychotic. [from NCI]

MedGen UID:
76370
Concept ID:
C0282126
Mental or Behavioral Dysfunction
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