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Acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is associated with 2 cardinal features: a granulocytic differentiation block and reciprocal and balanced translocations that always involve rearrangement of the RARA gene (180240). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (102578) and represents more than 98% of APL (Vitoux et al., 2007). [from OMIM]
Progressive multifocal leukoencephalopathy
A progressive demyelination within the central nervous system associated with reactivation of a latent JC virus infection. [from NCI]
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