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Items: 4

1.

Esomeprazole

The S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell. [from NCI]

MedGen UID:
215246
Concept ID:
C0937846
Organic Chemical; Pharmacologic Substance
2.

Proton pump inhibitor

Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. [from NCI]

MedGen UID:
87634
Concept ID:
C0358591
Pharmacologic Substance
3.

Esophagitis

An acute or chronic inflammatory process affecting the esophageal wall. [from NCI]

MedGen UID:
4549
Concept ID:
C0014868
Disease or Syndrome
4.

Erosive esophagitis

MedGen UID:
540356
Concept ID:
C0267055
Disease or Syndrome
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