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Items: 11

1.

Aging

Progressive damage to mitochondrial DNA (mtDNA) during life is thought to contribute to aging processes. This notion is supported by the observation of an aging-related accumulation in human mtDNA of oxidative and alkylation derivatives of nucleotides, of small deletions and insertions, and of large deletions, although their low frequency raises questions about their functional significance (Michikawa et al., 1999). [from GTR]

MedGen UID:
1376
Concept ID:
C0001811
Organism Function
2.

Cysteamine, 35S-Labeled

MedGen UID:
164594
Concept ID:
C0887464
Organic Chemical; Pharmacologic Substance
3.

Becaptan

MedGen UID:
152636
Concept ID:
C0729097
Organic Chemical; Pharmacologic Substance
4.

Cystagon

MedGen UID:
147608
Concept ID:
C0733368
Organic Chemical; Pharmacologic Substance
5.

Cysteamine

A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS. [from MeSH]

MedGen UID:
41390
Concept ID:
C0010648
Organic Chemical; Pharmacologic Substance
6.

DNA damage

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
7.

Agents, Cystine Depleting

Compounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS. [from MeSH]

MedGen UID:
827266
Concept ID:
C3850172
Pharmacologic Substance
8.

Cystine Disulfide Reducing Agents

MedGen UID:
827195
Concept ID:
C3850101
Pharmacologic Substance
9.

Cysteamine Maleate (1:1)

MedGen UID:
168327
Concept ID:
C0887465
Organic Chemical; Pharmacologic Substance
10.

Cysteamine Hydrobromide

MedGen UID:
168326
Concept ID:
C0887463
Organic Chemical; Pharmacologic Substance
11.

Cysteamine Tosylate

MedGen UID:
168325
Concept ID:
C0887462
Organic Chemical; Pharmacologic Substance
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