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1.

Erythromelalgia

A peripheral arterial disease that is characterized by the triad of ERYTHEMA, burning PAIN, and increased SKIN TEMPERATURE of the extremities (or red, painful extremities). Erythromelalgia may be classified as primary or idiopathic, familial or non-familial. Secondary erythromelalgia is associated with other diseases, the most common being MYELOPROLIFERATIVE DISORDERS. [from MeSH]

MedGen UID:
8687
Concept ID:
C0014804
Disease or Syndrome
2.

Excitability

MedGen UID:
536361
Concept ID:
C0235169
Sign or Symptom
3.

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). [from NCI]

MedGen UID:
109303
Concept ID:
C0596988
Cell or Molecular Dysfunction
4.

Primary erythromelalgia

SCN9A-related inherited erythromelalgia (SCN9A-related IEM) is characterized by recurrent attacks of bilateral and symmetric intense pain, redness, warmth, and swelling involving the feet and, less frequently, the hands. SCN9A-related IEM is not associated with an organic disease. Manifestations may vary within a family. Onset is usually in childhood or adolescence but has been recognized in infants and adults. At onset, episodes are triggered by warmth; other precipitating factors include: exercise, tight shoes, wearing socks, alcohol, spicy foods, and other vasodilating agents. In advanced disease, symptoms may occur many times a day or become constant. Some individuals have allodynia (pain evoked by a normally innocuous stimulus) and hyperalgesia (increased sensitivity to a painful stimulus). Episodes may be disabling, interfere with sleep, and severely limit normal activities such as walking, participation in sports, wearing socks and shoes, and attending school or going to work. [from GTR]

MedGen UID:
8688
Concept ID:
C0014805
Disease or Syndrome
5.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
6.

Pain

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. [from MeSH]

MedGen UID:
45282
Concept ID:
C0030193
Sign or Symptom
7.

Inherited Erythromelalgia

MedGen UID:
893359
Concept ID:
CN239438
Disease or Syndrome
8.

Pain

MedGen UID:
880950
Concept ID:
CN236637
Disease or Syndrome
9.

Triggered by

A trigger is defined as an external factor that leads to the manifestation of a sign or symptom in a person with a susceptibility to developing that manifestation. [from HPO]

MedGen UID:
252950
Concept ID:
C1444748
Qualitative Concept
10.

Peripheral neuropathy

A disorder affecting the cranial nerves or the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs. [from NCI]

MedGen UID:
141046
Concept ID:
C0442874
Disease or Syndrome
11.

Functional disorder

Deranged function in an individual or an organ that is due to a disease. (MedicineNet.com) [from NCI]

MedGen UID:
124450
Concept ID:
C0277785
Pathologic Function
12.

Suffering, Physical

MedGen UID:
148302
Concept ID:
C0751408
Sign or Symptom
13.

Pain, Migratory

MedGen UID:
148301
Concept ID:
C0751407
Sign or Symptom
14.

Crushing pain

A sense of discomfort or distress that is squeezing or excessively compressing. [from NCI]

MedGen UID:
141603
Concept ID:
C0458259
Sign or Symptom
15.

Splitting pain

An intense sensation of discomfort or distress that feels like being cut apart. [from NCI]

MedGen UID:
141602
Concept ID:
C0458257
Sign or Symptom
16.

Aching sensation quality

A dull persistent (usually moderately intense) pain. [from NCI]

MedGen UID:
115949
Concept ID:
C0234238
Sign or Symptom
17.

Radiating pain

A sensation of discomfort or distress that spreads from one anatomic location to another. [from NCI]

MedGen UID:
68587
Concept ID:
C0234254
Sign or Symptom
18.

Burning pain

A sensation of intensley hot or searing discomfort. [from NCI]

MedGen UID:
65867
Concept ID:
C0234230
Sign or Symptom
19.

Peripheral Vascular Diseases

Any disorder affecting blood flow through the veins or arteries outside of the heart. [from NCI]

MedGen UID:
38790
Concept ID:
C0085096
Disease or Syndrome
20.

Vascular disorder

A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma. [from NCI]

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
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