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Items: 13

1.

Osteoarthritis susceptibility 1

Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading to significant disability and joint replacement. Osteoarthritis exhibits a clear predilection for specific joints; it appears most commonly in the hip and knee joints and lumbar and cervical spine, as well as in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints of the hand; however, patients with osteoarthritis may have 1, a few, or all of these sites affected (Stefansson et al., 2003). According to a conservative estimate, greater than 70% of the population of the United States at age 65 years is affected by the disease, reflecting its age dependence. Genetic Heterogeneity of Susceptibility to Osteoarthritis Susceptibility to osteoarthritis has been associated with variation in other genes: OS2 (140600) with variation in the MATN3 gene (602109) on chromosome 2p24; OS3 (607850) with variation in the ASPN gene (608135) on chromosome 9q22; and OS5 (612400) with variation in the GDF5 gene (601146) on chromosome 20q11. Other susceptibility loci for osteoarthritis have been mapped to chromosomes 2q33 (OS4; 610839) and 3p24 (OS6; 612401). [from GTR]

MedGen UID:
45244
Concept ID:
C0029408
Disease or Syndrome
2.

Moderate

Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
525853
Concept ID:
C0205081
Qualitative Concept
3.

Osteoarthritis

MedGen UID:
505348
Concept ID:
CN002503
Finding
4.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
5.

Debrase

Gel dressing used for debridement (cleaning) of deep burns in hospitalized patients. [from MeSH]

MedGen UID:
416349
Concept ID:
C2930713
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
6.

Dontisanin

MedGen UID:
260641
Concept ID:
C1449926
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
7.

Bromelain POS

MedGen UID:
260640
Concept ID:
C1449925
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
8.

Proteozym

MedGen UID:
259624
Concept ID:
C1449941
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
9.

Extranase

MedGen UID:
258601
Concept ID:
C1449940
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
10.

Mucozym

MedGen UID:
258595
Concept ID:
C1449927
Amino Acid, Peptide, or Protein; Pharmacologic Substance
11.

Traumanase

MedGen UID:
146973
Concept ID:
C0699221
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
12.

Ananase

MedGen UID:
146415
Concept ID:
C0699220
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
13.

Bromelains

A proteolytic enzyme obtained from the pineapple plant that cleaves sulfhydryl groups. The enzyme is adsorbed intact through the gastrointestinal tract and has demonstrated therapeutic benefit. Bromelain has the ability to modulate cytokines, and has also demonstrated anti-inflammatory activity, immune response activity, and fibrinolytic activity. [from NCI]

MedGen UID:
14227
Concept ID:
C0006217
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
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