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Citalopram

MedGen UID:
979
Concept ID:
C0008845
Organic Chemical; Pharmacologic Substance
Synonyms: 5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-; Cytalopram
Drug response:
Citalopram response
MedGen UID:
808076
Concept ID:
CN221263
Sign or Symptom
Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of major depressive and anxiety disorders, and may be used to treat other psychiatric conditions. Citalopram/escitalopram are metabolized by cytochrome P450 2C19 (CYP2C19) and variations in CYP2C19 may affect drug exposure. Compared to extensive metabolizers, CYP2C19 ultrarapid metabolizers may have significantly lower exposure to citalopram/escitalopram while elevated concentrations of these drugs have been observed in poor metabolizers. Therapeutic guidelines for the SSRIs citalopram/escitalopram based on CYP2C19 genotype have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB website.
SNOMED CT: Citalopram (372596005); Citalopram (321986007)
 

Definition

A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCitalopram

Recent clinical studies

Etiology

Rector TS, Adabag S, Cunningham F, Nelson D, Dieperink E
Am J Psychiatry 2016 Sep 1;173(9):896-902. Epub 2016 May 10 doi: 10.1176/appi.ajp.2016.15111444. PMID: 27166093
Leonpacher AK, Peters ME, Drye LT, Makino KM, Newell JA, Devanand DP, Frangakis C, Munro CA, Mintzer JE, Pollock BG, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, Porsteinsson AP; CitAD Research Group.
Am J Psychiatry 2016 May 1;173(5):473-80. Epub 2016 Apr 1 doi: 10.1176/appi.ajp.2016.15020248. PMID: 27032628
Davari-Tanha F, Soleymani-Farsani M, Asadi M, Shariat M, Shirazi M, Hadizadeh H
Arch Gynecol Obstet 2016 May;293(5):1007-13. Epub 2015 Oct 5 doi: 10.1007/s00404-015-3900-1. PMID: 26437957
Weintraub D, Drye LT, Porsteinsson AP, Rosenberg PB, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Schneider LS, Shade DM, Yesavage J, Lyketsos CG; CitAD Research Group.
Am J Geriatr Psychiatry 2015 Nov;23(11):1127-33. Epub 2015 May 19 doi: 10.1016/j.jagp.2015.05.006. PMID: 26238225Free PMC Article
Charney DA, Heath LM, Zikos E, Palacios-Boix J, Gill KJ
Alcohol Clin Exp Res 2015 Sep;39(9):1756-65. Epub 2015 Jul 24 doi: 10.1111/acer.12802. PMID: 26208048

Diagnosis

Daneshvar L, Rounaghi GH, Es'haghi Z, Chamsaz M, Tarahomi S
Mater Sci Eng C Mater Biol Appl 2016 Dec 1;69:653-60. Epub 2016 Jul 14 doi: 10.1016/j.msec.2016.07.025. PMID: 27612758
Leonpacher AK, Peters ME, Drye LT, Makino KM, Newell JA, Devanand DP, Frangakis C, Munro CA, Mintzer JE, Pollock BG, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, Porsteinsson AP; CitAD Research Group.
Am J Psychiatry 2016 May 1;173(5):473-80. Epub 2016 Apr 1 doi: 10.1176/appi.ajp.2016.15020248. PMID: 27032628
Ghaedi H, Afkhami A, Madrakian T, Soltani-Felehgari F
Mater Sci Eng C Mater Biol Appl 2016 Feb;59:847-54. Epub 2015 Oct 30 doi: 10.1016/j.msec.2015.10.088. PMID: 26652440
Charney DA, Heath LM, Zikos E, Palacios-Boix J, Gill KJ
Alcohol Clin Exp Res 2015 Sep;39(9):1756-65. Epub 2015 Jul 24 doi: 10.1111/acer.12802. PMID: 26208048
Lavretsky H, Reinlieb M, St Cyr N, Siddarth P, Ercoli LM, Senturk D
Am J Psychiatry 2015 Jun;172(6):561-9. Epub 2015 Feb 13 doi: 10.1176/appi.ajp.2014.14070889. PMID: 25677354Free PMC Article

Therapy

Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N; collaborators of the SSRI-Breast Milk study.
J Pharm Biomed Anal 2016 Nov 30;131:233-245. Epub 2016 Aug 20 doi: 10.1016/j.jpba.2016.08.014. PMID: 27606925
Rector TS, Adabag S, Cunningham F, Nelson D, Dieperink E
Am J Psychiatry 2016 Sep 1;173(9):896-902. Epub 2016 May 10 doi: 10.1176/appi.ajp.2016.15111444. PMID: 27166093
Davari-Tanha F, Soleymani-Farsani M, Asadi M, Shariat M, Shirazi M, Hadizadeh H
Arch Gynecol Obstet 2016 May;293(5):1007-13. Epub 2015 Oct 5 doi: 10.1007/s00404-015-3900-1. PMID: 26437957
Weintraub D, Drye LT, Porsteinsson AP, Rosenberg PB, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Schneider LS, Shade DM, Yesavage J, Lyketsos CG; CitAD Research Group.
Am J Geriatr Psychiatry 2015 Nov;23(11):1127-33. Epub 2015 May 19 doi: 10.1016/j.jagp.2015.05.006. PMID: 26238225Free PMC Article
Charney DA, Heath LM, Zikos E, Palacios-Boix J, Gill KJ
Alcohol Clin Exp Res 2015 Sep;39(9):1756-65. Epub 2015 Jul 24 doi: 10.1111/acer.12802. PMID: 26208048

Prognosis

Coughlin CG, Jakubovski E, Bloch MH
J Clin Psychiatry 2016 Oct;77(10):e1262-e1269. doi: 10.4088/JCP.15m10075. PMID: 27631142
Rector TS, Adabag S, Cunningham F, Nelson D, Dieperink E
Am J Psychiatry 2016 Sep 1;173(9):896-902. Epub 2016 May 10 doi: 10.1176/appi.ajp.2016.15111444. PMID: 27166093
Schneider LS, Frangakis C, Drye LT, Devanand DP, Marano CM, Mintzer J, Mulsant BH, Munro CA, Newell JA, Pawluczyk S, Pelton G, Pollock BG, Porsteinsson AP, Rabins PV, Rein L, Rosenberg PB, Shade D, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group.
Am J Psychiatry 2016 May 1;173(5):465-72. Epub 2016 Jan 15 doi: 10.1176/appi.ajp.2015.15050648. PMID: 26771737
Weintraub D, Drye LT, Porsteinsson AP, Rosenberg PB, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Schneider LS, Shade DM, Yesavage J, Lyketsos CG; CitAD Research Group.
Am J Geriatr Psychiatry 2015 Nov;23(11):1127-33. Epub 2015 May 19 doi: 10.1016/j.jagp.2015.05.006. PMID: 26238225Free PMC Article
Charney DA, Heath LM, Zikos E, Palacios-Boix J, Gill KJ
Alcohol Clin Exp Res 2015 Sep;39(9):1756-65. Epub 2015 Jul 24 doi: 10.1111/acer.12802. PMID: 26208048

Clinical prediction guides

Leonpacher AK, Peters ME, Drye LT, Makino KM, Newell JA, Devanand DP, Frangakis C, Munro CA, Mintzer JE, Pollock BG, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, Porsteinsson AP; CitAD Research Group.
Am J Psychiatry 2016 May 1;173(5):473-80. Epub 2016 Apr 1 doi: 10.1176/appi.ajp.2016.15020248. PMID: 27032628
Schneider LS, Frangakis C, Drye LT, Devanand DP, Marano CM, Mintzer J, Mulsant BH, Munro CA, Newell JA, Pawluczyk S, Pelton G, Pollock BG, Porsteinsson AP, Rabins PV, Rein L, Rosenberg PB, Shade D, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group.
Am J Psychiatry 2016 May 1;173(5):465-72. Epub 2016 Jan 15 doi: 10.1176/appi.ajp.2015.15050648. PMID: 26771737
Davari-Tanha F, Soleymani-Farsani M, Asadi M, Shariat M, Shirazi M, Hadizadeh H
Arch Gynecol Obstet 2016 May;293(5):1007-13. Epub 2015 Oct 5 doi: 10.1007/s00404-015-3900-1. PMID: 26437957
Weintraub D, Drye LT, Porsteinsson AP, Rosenberg PB, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Schneider LS, Shade DM, Yesavage J, Lyketsos CG; CitAD Research Group.
Am J Geriatr Psychiatry 2015 Nov;23(11):1127-33. Epub 2015 May 19 doi: 10.1016/j.jagp.2015.05.006. PMID: 26238225Free PMC Article
Charney DA, Heath LM, Zikos E, Palacios-Boix J, Gill KJ
Alcohol Clin Exp Res 2015 Sep;39(9):1756-65. Epub 2015 Jul 24 doi: 10.1111/acer.12802. PMID: 26208048

Recent systematic reviews

Tan S, Huang X, Ding L, Hong H
Eur Neurol 2015;74(3-4):188-201. Epub 2015 Nov 12 doi: 10.1159/000441446. PMID: 26559658
Tampi RR, Balderas M, Carter KV, Tampi DJ, Moca M, Knudsen A, May J
Psychosomatics 2015 Jan-Feb;56(1):36-43. Epub 2014 Sep 6 doi: 10.1016/j.psym.2014.09.002. PMID: 25619672
Chang M, Tybring G, Dahl ML, Lindh JD
Clin Pharmacokinet 2014 Sep;53(9):801-11. doi: 10.1007/s40262-014-0162-1. PMID: 25154506
Alkhafaji AA, Trinquart L, Baron G, Desvarieux M, Ravaud P
BMC Med 2012 Nov 20;10:142. doi: 10.1186/1741-7015-10-142. PMID: 23167972Free PMC Article
Cipriani A, Purgato M, Furukawa TA, Trespidi C, Imperadore G, Signoretti A, Churchill R, Watanabe N, Barbui C
Cochrane Database Syst Rev 2012 Jul 11;(7):CD006534. doi: 10.1002/14651858.CD006534.pub2. PMID: 22786497Free PMC Article

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