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Silymarin

MedGen UID:
11433
Concept ID:
C0037135
Organic Chemical; Pharmacologic Substance
Synonyms: Silimarin
 

Definition

A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. (NCI04) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSilymarin

Recent clinical studies

Etiology

Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G
Phytother Res 2016 Nov;30(11):1879-1885. Epub 2016 Aug 23 doi: 10.1002/ptr.5704. PMID: 27555604
Firuzi O, Khajehrezaei S, Ezzatzadegan S, Nejati M, Jahanshahi KA, Roozbeh J
Hemodial Int 2016 Oct;20(4):558-563. Epub 2016 Apr 4 doi: 10.1111/hdi.12413. PMID: 27040041
Shahbazi F, Sadighi S, Dashti-Khavidaki S, Shahi F, Mirzania M, Abdollahi A, Ghahremani MH
Phytother Res 2015 Jul;29(7):1046-53. Epub 2015 Apr 7 doi: 10.1002/ptr.5345. PMID: 25857366
Ebrahimpour Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M
Phytomedicine 2015 Feb 15;22(2):290-6. Epub 2015 Jan 19 doi: 10.1016/j.phymed.2014.12.010. PMID: 25765835
Rastegarpanah M, Malekzadeh R, Vahedi H, Mohammadi M, Elahi E, Chaharmahali M, Safarnavadeh T, Abdollahi M
Chin J Integr Med 2015 Dec;21(12):902-6. Epub 2012 Apr 11 doi: 10.1007/s11655-012-1026-x. PMID: 22528757

Diagnosis

Aller R, Izaola O, Gómez S, Tafur C, González G, Berroa E, Mora N, González JM, de Luis DA
Eur Rev Med Pharmacol Sci 2015 Aug;19(16):3118-24. PMID: 26367736
Hagag AA, Elfaragy MS, Elrifaey SM, Abd El-Lateef AE
Infect Disord Drug Targets 2015;15(3):189-95. PMID: 26239735
Brinda BJ, Zhu HJ, Markowitz JS
J Chromatogr B Analyt Technol Biomed Life Sci 2012 Aug 1;902:1-9. Epub 2012 Jun 12 doi: 10.1016/j.jchromb.2012.06.003. PMID: 22766231
Bakhshaee M, Jabbari F, Hoseini S, Farid R, Sadeghian MH, Rajati M, Mohamadpoor AH, Movahhed R, Zamani MA
Otolaryngol Head Neck Surg 2011 Dec;145(6):904-9. Epub 2011 Sep 27 doi: 10.1177/0194599811423504. PMID: 21952357
Colombo V, Lupi M, Falcetta F, Forestieri D, D'Incalci M, Ubezio P
Cancer Chemother Pharmacol 2011 Feb;67(2):369-79. Epub 2010 Apr 30 doi: 10.1007/s00280-010-1335-8. PMID: 20431887

Therapy

Federico A, Dallio M, Loguercio C
Molecules 2017 Jan 24;22(2) doi: 10.3390/molecules22020191. PMID: 28125040
Stolf AM, Cardoso CC, Acco A
Phytother Res 2017 Mar;31(3):366-374. Epub 2017 Jan 25 doi: 10.1002/ptr.5768. PMID: 28124457
Xie Y, Miranda SR, Hoskins JM, Hawke RL
Molecules 2017 Jan 15;22(1) doi: 10.3390/molecules22010142. PMID: 28098838
Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G
Phytother Res 2016 Nov;30(11):1879-1885. Epub 2016 Aug 23 doi: 10.1002/ptr.5704. PMID: 27555604
Firuzi O, Khajehrezaei S, Ezzatzadegan S, Nejati M, Jahanshahi KA, Roozbeh J
Hemodial Int 2016 Oct;20(4):558-563. Epub 2016 Apr 4 doi: 10.1111/hdi.12413. PMID: 27040041

Prognosis

Shahbazi F, Sadighi S, Dashti-Khavidaki S, Shahi F, Mirzania M, Abdollahi A, Ghahremani MH
Phytother Res 2015 Jul;29(7):1046-53. Epub 2015 Apr 7 doi: 10.1002/ptr.5345. PMID: 25857366
Belcaro G, Hu S, Gizzi G, Corsi M, Dugall M, Hu S, Pellegrini L, Ledda A, Cornelli U, Cesarone MR, Hosoi M, Luzzi R
Minerva Med 2014 Dec;105(6 Suppl 2):17-25. PMID: 26076377
Yang Z, Zhuang L, Lu Y, Xu Q, Chen X
Biomed Res Int 2014;2014:941085. Epub 2014 Aug 27 doi: 10.1155/2014/941085. PMID: 25247194Free PMC Article
Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP
CNS Neurosci Ther 2013 Nov;19(11):847-53. Epub 2013 Oct 14 doi: 10.1111/cns.12175. PMID: 24118806
Bakhshaee M, Jabbari F, Hoseini S, Farid R, Sadeghian MH, Rajati M, Mohamadpoor AH, Movahhed R, Zamani MA
Otolaryngol Head Neck Surg 2011 Dec;145(6):904-9. Epub 2011 Sep 27 doi: 10.1177/0194599811423504. PMID: 21952357

Clinical prediction guides

Xie Y, Miranda SR, Hoskins JM, Hawke RL
Molecules 2017 Jan 15;22(1) doi: 10.3390/molecules22010142. PMID: 28098838
Elyasi S, Hosseini S, Niazi Moghadam MR, Aledavood SA, Karimi G
Phytother Res 2016 Nov;30(11):1879-1885. Epub 2016 Aug 23 doi: 10.1002/ptr.5704. PMID: 27555604
Aller R, Izaola O, Gómez S, Tafur C, González G, Berroa E, Mora N, González JM, de Luis DA
Eur Rev Med Pharmacol Sci 2015 Aug;19(16):3118-24. PMID: 26367736
Rastegarpanah M, Malekzadeh R, Vahedi H, Mohammadi M, Elahi E, Chaharmahali M, Safarnavadeh T, Abdollahi M
Chin J Integr Med 2015 Dec;21(12):902-6. Epub 2012 Apr 11 doi: 10.1007/s11655-012-1026-x. PMID: 22528757
Balouchi S, Gharagozloo M, Esmaeil N, Mirmoghtadaei M, Moayedi B
Immunopharmacol Immunotoxicol 2014 Aug;36(4):271-4. Epub 2014 Jun 19 doi: 10.3109/08923973.2014.926916. PMID: 24945737

Recent systematic reviews

Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A
J Diabetes Res 2016;2016:5147468. Epub 2016 Jun 1 doi: 10.1155/2016/5147468. PMID: 27340676Free PMC Article
Mastron JK, Siveen KS, Sethi G, Bishayee A
Anticancer Drugs 2015 Jun;26(5):475-86. doi: 10.1097/CAD.0000000000000211. PMID: 25603021
Yang Z, Zhuang L, Lu Y, Xu Q, Chen X
Biomed Res Int 2014;2014:941085. Epub 2014 Aug 27 doi: 10.1155/2014/941085. PMID: 25247194Free PMC Article
Wei F, Liu SK, Liu XY, Li ZJ, Li B, Zhou YL, Zhang HY, Li YW
Eur J Clin Microbiol Infect Dis 2013 May;32(5):657-69. Epub 2012 Dec 18 doi: 10.1007/s10096-012-1789-1. PMID: 23247631
Saller R, Brignoli R, Melzer J, Meier R
Forsch Komplementmed 2008 Feb;15(1):9-20. doi: 10.1159/000113648. PMID: 18334810

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