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Items: 1 to 20 of 33

1.

Transmission

A passage or transfer, as of a disease from one individual to another. [from NCI]

MedGen UID:
66979
Concept ID:
C0242781
Pathologic Function
2.

Parasitemia

The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed) [from MeSH]

MedGen UID:
116650
Concept ID:
C0242723
Disease or Syndrome
3.

Dihydrofolate

MedGen UID:
28140
Concept ID:
C0058075
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
4.

Sulfadoxine product

A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. Sulfadoxine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of parasitic folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death. [from NCI]

MedGen UID:
21387
Concept ID:
C0038679
Organic Chemical; Pharmacologic Substance
5.

Pyrimethamine

A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04) [from NCI]

MedGen UID:
11062
Concept ID:
C0034283
Organic Chemical; Pharmacologic Substance
6.

Disease due to Plasmodiidae

A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. [from MeSH]

MedGen UID:
7443
Concept ID:
C0024530
Disease or Syndrome
7.

Regression

Return to a former state; a subsidence of the symptoms of a disease process; in cancer, a decrease in the size of a tumor or in the extent of cancer in the body. [from NCI]

MedGen UID:
195771
Concept ID:
C0684320
Pathologic Function
8.

Familial porphyria cutanea tarda

Familial porphyria cutanea tarda (F-PCT) is characterized by: skin findings including blistering over the dorsal aspects of the hands and other sun-exposed areas of skin, skin friability after minor trauma, facial hypertrichosis and hyperpigmentation, and severe thickening of affected skin areas (pseudoscleroderma); and an increased risk for hepatocellular carcinoma (HCC). [from GTR]

MedGen UID:
75669
Concept ID:
C0268323
Disease or Syndrome
9.

Heterogeneous

The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992) [from MeSH]

MedGen UID:
67020
Concept ID:
C0242960
Organism Attribute
10.

Porphyria cutanea tarda

A cutaneous form of the genetic photosensitive disease, porphyria, that is characterized by onset in adult life and the presence of scarring bullae, hyperpigmentation, facial hypertrichosis, and sometimes sclerodermatous thickenings and alopecia. Uroporphyrins are found in the urine due to a deficiency of uroporphyrinogen decarboxylase, an enzyme required for the synthesis of heme. [from NCI]

MedGen UID:
56453
Concept ID:
C0162566
Disease or Syndrome
11.

Schizonticides

Substances that inhibit the SCHIZONTS stage of protozoa. There is particular interest in them as ANTIMALARIALS. [from MeSH]

MedGen UID:
354500
Concept ID:
C1720748
Pharmacologic Substance
12.

Malocide

MedGen UID:
296027
Concept ID:
C1564292
Organic Chemical; Pharmacologic Substance
13.

Antimicrobial substance

Generically, any agent that destroys microbes. However, usage of the term is increasingly being confined to agents that prevent or reduce the transmission of SEXUALLY TRANSMITTED DISEASES. [from MeSH]

MedGen UID:
209727
Concept ID:
C1136254
Pharmacologic Substance
14.

Fanasil

MedGen UID:
152647
Concept ID:
C0729134
Organic Chemical; Pharmacologic Substance
15.

Tindurine

MedGen UID:
149137
Concept ID:
C0733441
Organic Chemical; Pharmacologic Substance
16.

Chloridin

MedGen UID:
149135
Concept ID:
C0733439
Organic Chemical; Pharmacologic Substance
17.

Daraprim

MedGen UID:
108800
Concept ID:
C0591326
Organic Chemical; Pharmacologic Substance
18.

Point mutation

A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair. [from MeSH]

MedGen UID:
56498
Concept ID:
C0162735
Cell or Molecular Dysfunction
19.

Disease caused by parasite

Infections or infestations with PARASITES. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure. [from MeSH]

MedGen UID:
45325
Concept ID:
C0030499
Disease or Syndrome
20.

Drug Combinations

Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. [from MeSH]

MedGen UID:
41661
Concept ID:
C0013162
Pharmacologic Substance
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