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Items: 9

1.

Dehydration

A condition resulting from the excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis. [from NCI]

MedGen UID:
8273
Concept ID:
C0011175
Disease or Syndrome
2.

Process

MedGen UID:
923307
Concept ID:
C1951340
Pharmacologic Substance
3.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
4.

NSC-38297

MedGen UID:
163893
Concept ID:
C0878530
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5.

Uridine

A nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine has been studied as a rescue agent to reduce the toxicities associated with 5-fluorouracil (5-FU), thereby allowing the administration of higher doses of 5-FU in chemotherapy regimens. (NCI04) [from NCI]

MedGen UID:
22572
Concept ID:
C0041984
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
6.

Photolysis

Chemical bond cleavage reactions resulting from absorption of radiant energy. [from MeSH]

MedGen UID:
10748
Concept ID:
C0031751
Molecular Function
7.

DNA damage

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
8.

Broxuridine

A halogenated thymidine analogue with potential antineoplastic and radiosensitizing activities. Bromodeoxyuridine competes with thymidine for incorporation into DNA, resulting in DNA mutation and the inhibition of cell proliferation. As a radiosensitizer, this agent is associated with the inhibition of repair of radiation-induced DNA double-strand breaks. [from NCI]

MedGen UID:
2358
Concept ID:
C0006233
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
9.

Dehydration due to radiation

MedGen UID:
841395
Concept ID:
C3875560
Disease or Syndrome
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