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Items: 20

1.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
2.

Bromocriptine

A semisynthetic ergotamine alkaloid that is a dopamine D2 agonist. It suppresses prolactin secretion. [from MeSH]

MedGen UID:
661
Concept ID:
C0006230
Organic Chemical; Pharmacologic Substance
3.

Agonist

An agent that has affinity for a receptor and intrinsic activity at that receptor. [from NCI]

MedGen UID:
459858
Concept ID:
C2987634
Pharmacologic Substance
4.

Dopamine agonist product

Any agent that binds to and activates dopamine receptors. [from NCI]

MedGen UID:
59817
Concept ID:
C0178601
Pharmacologic Substance
5.

Substance abuse

Maladaptive pattern of drug or alcohol use that may lead to social, occupational, psychological, or physical problems. [from NCI]

MedGen UID:
152849
Concept ID:
C0740858
Mental or Behavioral Dysfunction
6.

AGON

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
7.

Genetic anticipation

A mode of inheritance in which the severity of a disorder increases or the age of onset decreases as the disorder is passed from one generation to the next. [from HPO]

MedGen UID:
109454
Concept ID:
C0600498
Organism Attribute
8.

Substance abuse

MedGen UID:
880105
Concept ID:
C2364059
9.

Resonance

MedGen UID:
534094
Concept ID:
C0231881
Finding
10.

Addictive behavior

A recurrent pattern of behavior that is characeterized by the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the person or to others. The repetitive engagement in these behaviors ultimately interferes with functioning in other domains. [from HPO]

MedGen UID:
88373
Concept ID:
C0085281
Mental or Behavioral Dysfunction
11.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
12.

Ergoline drug

MedGen UID:
215324
Concept ID:
C0949288
Organic Chemical; Pharmacologic Substance
13.

CB-154

MedGen UID:
152301
Concept ID:
C0701351
Organic Chemical; Pharmacologic Substance
14.

Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. [from MeSH]

MedGen UID:
69321
Concept ID:
C0243051
Pharmacologic Substance
15.

Oxygen

An element with atomic symbol O, atomic number 8, and atomic weight 16. [from NCI]

MedGen UID:
45267
Concept ID:
C0030054
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
16.

Alkaloid

A family or group of nitrogen-containing base compounds primarily derived from plant and animal sources. Many alkaloids are used medicinally, including cancer therapy. [from NCI]

MedGen UID:
7968
Concept ID:
C0002062
Organic Chemical; Pharmacologic Substance
17.

Ergot alkaloid

Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Many of the ergot alkaloids act as alpha-adrenergic antagonists. [from MeSH]

MedGen UID:
4522
Concept ID:
C0014707
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
18.

Agents, Dopaminergic

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. [from MeSH]

MedGen UID:
4380
Concept ID:
C0013036
Pharmacologic Substance
19.

Parlodel

MedGen UID:
1646
Concept ID:
C0000266
Organic Chemical; Pharmacologic Substance
20.

Psychological abuse of adult

MedGen UID:
629087
Concept ID:
C0456221
Mental or Behavioral Dysfunction
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