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Items: 1 to 20 of 22

1.

Genotoxic Stress

Exposure to DNA-damaging agents and subsequent energy expenditures by a cell to repair DNA damage. Genotoxic stress elicits biochemical responses that either enhance cell survival or lead to cell death. These biochemical responses include DNA-damage-inducible repair and increasing expression of a variety of proteins by both transcriptional and post-transcriptional mechanisms. Genotoxic stresses frequently activate signal transduction pathways that originate in the cell membrane or cytoplasm, triggering similar phosphorylation cascades to those induced by the activation of cell-surface receptors. [from NCI]

MedGen UID:
222489
Concept ID:
C1257899
Cell or Molecular Dysfunction
2.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
3.

DNA damage

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
4.

Stabilized

Condition did not change and required not further care to maintain condition [from CCC]

MedGen UID:
512205
Concept ID:
C0184512
Finding
5.

Dephosphorylation

The catalyzed removal of phosphate groups from biological molecules, by phosphatases. [from NCI]

MedGen UID:
463624
Concept ID:
C3160734
Molecular Function
6.

Triggered by

Something that sets into motion some course of events; a device that activates or releases or causes something to happen. [from NCI]

MedGen UID:
252950
Concept ID:
C1444748
Qualitative Concept
7.

Onset

The age group in which disease manifestations appear. [from HPO]

MedGen UID:
64519
Concept ID:
C0206132
Quantitative Concept
8.

Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities. [from NCI]

MedGen UID:
20971
Concept ID:
C0038435
Finding
9.

Adriablastin

MedGen UID:
423645
Concept ID:
C2936928
Organic Chemical; Pharmacologic Substance
10.

Farmiblastina

MedGen UID:
307476
Concept ID:
C1512059
Organic Chemical; Pharmacologic Substance
11.

Onkodox

MedGen UID:
297409
Concept ID:
C1564916
Organic Chemical; Pharmacologic Substance
12.

Ribodoxo

MedGen UID:
289948
Concept ID:
C1564915
Organic Chemical; Pharmacologic Substance
13.

Doxotec

MedGen UID:
289075
Concept ID:
C1564914
Organic Chemical; Pharmacologic Substance
14.

Doxolem

MedGen UID:
268094
Concept ID:
C1512057
Organic Chemical; Pharmacologic Substance
15.

DOXO-CELL

MedGen UID:
268093
Concept ID:
C1512056
Organic Chemical; Pharmacologic Substance
16.

Adrimedac

MedGen UID:
268092
Concept ID:
C1512055
Organic Chemical; Pharmacologic Substance
17.

Rubex

MedGen UID:
195822
Concept ID:
C0699076
Organic Chemical; Pharmacologic Substance
18.

Cerubidine

MedGen UID:
148707
Concept ID:
C0701063
Organic Chemical; Pharmacologic Substance
19.

NSC-82151

MedGen UID:
148064
Concept ID:
C0733673
Organic Chemical; Pharmacologic Substance
20.

Daunoblastine

MedGen UID:
147208
Concept ID:
C0701062
Organic Chemical; Pharmacologic Substance
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