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Dopamine

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
Synonyms: 1,2-Benzenediol, 4-(2-aminoethyl)-; 3,4 Dihydroxyphenethylamine; 3,4-Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Hydroxytyramine
SNOMED CT: Dopamine product (59187003); Dopamine (412383006); Dopamine preparation (412383006); Dopamine agent (412383006); Dopamine (59187003); Hydroxytyramine (59187003)
 

Definition

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDopamine

Recent clinical studies

Etiology

Caminiti SP, Presotto L, Baroncini D, Garibotto V, Moresco RM, Gianolli L, Volonté MA, Antonini A, Perani D
Neuroimage Clin 2017;14:734-740. Epub 2017 Mar 27 doi: 10.1016/j.nicl.2017.03.011. PMID: 28409113Free PMC Article
Talemi RP, Mousavi SM, Afruzi H
Mater Sci Eng C Mater Biol Appl 2017 Apr 1;73:700-708. Epub 2016 Dec 26 doi: 10.1016/j.msec.2016.12.119. PMID: 28183663
Kahnt T, Tobler PN
J Neurosci 2017 Feb 8;37(6):1493-1504. Epub 2017 Jan 9 doi: 10.1523/JNEUROSCI.2827-16.2016. PMID: 28069917Free PMC Article
Howes OD, McCutcheon R, Owen MJ, Murray RM
Biol Psychiatry 2017 Jan 1;81(1):9-20. Epub 2016 Aug 6 doi: 10.1016/j.biopsych.2016.07.014. PMID: 27720198Free PMC Article
Tombeau Cost K, Unternaehrer E, Plamondon A, Steiner M, Meaney M, Atkinson L, Kennedy JL, Fleming AS; MAVAN Research Team.
Genes Brain Behav 2017 Feb;16(2):285-295. Epub 2016 Oct 21 doi: 10.1111/gbb.12337. PMID: 27620964

Diagnosis

Talemi RP, Mousavi SM, Afruzi H
Mater Sci Eng C Mater Biol Appl 2017 Apr 1;73:700-708. Epub 2016 Dec 26 doi: 10.1016/j.msec.2016.12.119. PMID: 28183663
Rehmani N, Zafar A, Arif H, Hadi SM, Wani AA
Toxicol In Vitro 2017 Apr;40:336-346. Epub 2017 Jan 28 doi: 10.1016/j.tiv.2017.01.020. PMID: 28137434Free PMC Article
Khamlichi RE, Bouchta D, Anouar EH, Atia MB, Attar A, Choukairi M, Tazi S, Ihssane R, Faiza C, Khalid D, Khalid RT
Mater Sci Eng C Mater Biol Appl 2017 Feb 1;71:870-878. Epub 2016 Nov 4 doi: 10.1016/j.msec.2016.10.076. PMID: 27987784
Matsuda Y, Kimura N, Yoshimoto T, Sekiguchi Y, Tomoishi J, Kasahara I, Hara Y, Ogawa Y
Endocr Pathol 2017 Mar;28(1):36-40. doi: 10.1007/s12022-016-9457-0. PMID: 27743246
Billino J, Hennig J, Gegenfurtner KR
eNeuro 2016 Nov-Dec;3(6) Epub 2017 Jan 10 doi: 10.1523/ENEURO.0190-16.2016. PMID: 28101524Free PMC Article

Therapy

Rui Q, Jiang Y, Chen M, Zhang N, Yang H, Zhou Y
Medicine (Baltimore) 2017 Oct;96(43):e8402. doi: 10.1097/MD.0000000000008402. PMID: 29069037Free PMC Article
Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H
Nat Neurosci 2017 Nov;20(11):1560-1568. Epub 2017 Sep 18 doi: 10.1038/nn.4641. PMID: 28920936
Yang X, Sun X, Chen H, Xi G, Hou Y, Wu J, Liu D, Wang H, Hou Y, Yu J
Int Immunopharmacol 2017 Apr;45:68-73. Epub 2017 Feb 8 doi: 10.1016/j.intimp.2017.02.002. PMID: 28189055
Kahnt T, Tobler PN
J Neurosci 2017 Feb 8;37(6):1493-1504. Epub 2017 Jan 9 doi: 10.1523/JNEUROSCI.2827-16.2016. PMID: 28069917Free PMC Article
Maia TV, Frank MJ
Biol Psychiatry 2017 Jan 1;81(1):52-66. Epub 2016 Jun 1 doi: 10.1016/j.biopsych.2016.05.021. PMID: 27452791Free PMC Article

Prognosis

Volkow ND, Wise RA, Baler R
Nat Rev Neurosci 2017 Nov 16;18(12):741-752. doi: 10.1038/nrn.2017.130. PMID: 29142296
Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang GJ, Fowler JS, Volkow ND
J Neurosci 2017 May 10;37(19):4982-4991. Epub 2017 Apr 17 doi: 10.1523/JNEUROSCI.3155-16.2017. PMID: 28416594Free PMC Article
Hao F, Wang S, Zhu X, Xue J, Li J, Wang L, Li J, Lu W, Zhou T
Pharm Res 2017 Feb;34(2):408-418. Epub 2016 Dec 14 doi: 10.1007/s11095-016-2071-5. PMID: 27975187
Maia TV, Frank MJ
Biol Psychiatry 2017 Jan 1;81(1):52-66. Epub 2016 Jun 1 doi: 10.1016/j.biopsych.2016.05.021. PMID: 27452791Free PMC Article
Lohrenz T, Kishida KT, Montague PR
Philos Trans R Soc Lond B Biol Sci 2016 Oct 5;371(1705) doi: 10.1098/rstb.2015.0352. PMID: 27574306Free PMC Article

Clinical prediction guides

Shumay E, Wiers CE, Shokri-Kojori E, Kim SW, Hodgkinson CA, Sun H, Tomasi D, Wong CT, Weinberger DR, Wang GJ, Fowler JS, Volkow ND
J Neurosci 2017 May 10;37(19):4982-4991. Epub 2017 Apr 17 doi: 10.1523/JNEUROSCI.3155-16.2017. PMID: 28416594Free PMC Article
Kahnt T, Tobler PN
J Neurosci 2017 Feb 8;37(6):1493-1504. Epub 2017 Jan 9 doi: 10.1523/JNEUROSCI.2827-16.2016. PMID: 28069917Free PMC Article
Hao F, Wang S, Zhu X, Xue J, Li J, Wang L, Li J, Lu W, Zhou T
Pharm Res 2017 Feb;34(2):408-418. Epub 2016 Dec 14 doi: 10.1007/s11095-016-2071-5. PMID: 27975187
Matsuda Y, Kimura N, Yoshimoto T, Sekiguchi Y, Tomoishi J, Kasahara I, Hara Y, Ogawa Y
Endocr Pathol 2017 Mar;28(1):36-40. doi: 10.1007/s12022-016-9457-0. PMID: 27743246
Feng XY, Zhang DN, Wang YA, Fan RF, Hong F, Zhang Y, Li Y, Zhu JX
Acta Physiol (Oxf) 2017 May;220(1):113-123. Epub 2016 Oct 6 doi: 10.1111/apha.12806. PMID: 27652590

Recent systematic reviews

Rui Q, Jiang Y, Chen M, Zhang N, Yang H, Zhou Y
Medicine (Baltimore) 2017 Oct;96(43):e8402. doi: 10.1097/MD.0000000000008402. PMID: 29069037Free PMC Article
Tahmasian M, Bettray LM, van Eimeren T, Drzezga A, Timmermann L, Eickhoff CR, Eickhoff SB, Eggers C
Cortex 2015 Dec;73:80-105. Epub 2015 Aug 14 doi: 10.1016/j.cortex.2015.08.005. PMID: 26386442
Abraham AD, Neve KA, Lattal KM
Neurobiol Learn Mem 2014 Feb;108:65-77. Epub 2013 Nov 20 doi: 10.1016/j.nlm.2013.11.007. PMID: 24269353Free PMC Article
Padmanabhan A, Luna B
Brain Cogn 2014 Aug;89:27-38. Epub 2013 Oct 17 doi: 10.1016/j.bandc.2013.09.011. PMID: 24139694Free PMC Article
Vaillancourt DE, Schonfeld D, Kwak Y, Bohnen NI, Seidler R
Mov Disord 2013 Dec;28(14):1920-9. Epub 2013 Oct 9 doi: 10.1002/mds.25687. PMID: 24123087Free PMC Article

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