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Items: 16

1.

Extrusion

Issue associated with the unintended of projection of device component materials. [from NCI_FDA]

MedGen UID:
96708
Concept ID:
C0443213
Finding
2.

Guanidine

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC. [from MeSH]

MedGen UID:
92574
Concept ID:
C0120446
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
3.

Tetraethylammonium

A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90) [from MeSH]

MedGen UID:
82238
Concept ID:
C0076252
Organic Chemical; Pharmacologic Substance
4.

Cimetidine

A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) [from NCI]

MedGen UID:
40309
Concept ID:
C0008783
Organic Chemical; Pharmacologic Substance
5.

verapamil

A calcium channel blocker that is a class IV anti-arrhythmia agent. [from MeSH]

MedGen UID:
21845
Concept ID:
C0042523
Organic Chemical; Pharmacologic Substance
6.

Quinidine

An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. [from NCI]

MedGen UID:
18811
Concept ID:
C0034414
Organic Chemical; Pharmacologic Substance
7.

Procainamide

A class Ia antiarrhythmic drug that is structurally-related to PROCAINE. [from MeSH]

MedGen UID:
18645
Concept ID:
C0033216
Organic Chemical; Pharmacologic Substance
8.

Quinine

A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) [from NCI]

MedGen UID:
11086
Concept ID:
C0034417
Organic Chemical; Pharmacologic Substance
9.

Metformin

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) [from MeSH]

MedGen UID:
7578
Concept ID:
C0025598
Organic Chemical; Pharmacologic Substance
10.

Ammonium chloride

A systemic and urinary acidifying salt. Ammonium chloride helps maintain pH and exerts a mild diuretic effect. This acid forming salt also exerts an expectorant effect by irritating the mucous membranes and is used for alleviation of cough. [from NCI]

MedGen UID:
261
Concept ID:
C0002615
Inorganic Chemical; Pharmacologic Substance
11.

Metformin

MedGen UID:
1095213
Concept ID:
CN425044
Pharmacologic Substance
12.

Localized

Being confined or restricted to a particular location. [from HPO]

MedGen UID:
98236
Concept ID:
C0392752
Spatial Concept
13.

Proximal

Localized close to the central point of the body. [from HPO]

MedGen UID:
64374
Concept ID:
C0205107
Spatial Concept
14.

Amino acid

Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins. [from NCI]

MedGen UID:
250
Concept ID:
C0002520
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
15.

Electrolyte

Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed) [from MeSH]

MedGen UID:
3997
Concept ID:
C0013832
Inorganic Chemical; Pharmacologic Substance
16.

Quinine Lafran

MedGen UID:
295948
Concept ID:
C1564022
Organic Chemical; Pharmacologic Substance
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