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Items: 18

1.

Heroin

Heroin is a white or brown powder or a black, sticky goo. It's made from morphine, a natural substance in the seedpod of the Asian poppy plant. It can be mixed with water and injected with a needle. Heroin can also be smoked or snorted up the nose. All of these ways of taking heroin send it to the brain very quickly. This makes it very addictive. Major health problems from heroin include miscarriages, heart infections, and death from overdose. People who inject the drug also risk getting infectious diseases, including HIV/AIDS and hepatitis. Regular use of heroin can lead to tolerance. This means users need more and more drug to have the same effect. At higher doses over time, the body becomes dependent on heroin. If dependent users stop heroin, they have withdrawal symptoms. These symptoms include restlessness, muscle and bone pain, diarrhea and vomiting, and cold flashes with goose bumps. . NIH: National Institute on Drug Abuse.  [from MedlinePlus]

MedGen UID:
41524
Concept ID:
C0011892
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
2.

Opiate agonist

A class of synthetic chemicals/drugs similar to opiates (opium derivatives) with analgesic properties. Due to binding to opiate receptors, opioids mimic opiate activity on neurons, various cells (i.e. lymphocytes), pain suppression and other neurobehavioral activity. (NCI) [from NCI]

MedGen UID:
66892
Concept ID:
C0242402
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
3.

Heroin Abuse

MedGen UID:
108675
Concept ID:
C0600241
Mental or Behavioral Dysfunction
4.

Heroin dependence

Strong dependence, both physiological and emotional, upon heroin. [from MeSH]

MedGen UID:
5532
Concept ID:
C0019337
Mental or Behavioral Dysfunction
5.

Down-regulation

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
4386
Concept ID:
C0013081
Molecular Function
6.

Heroin Dependence

MedGen UID:
881109
Concept ID:
CN236651
Disease or Syndrome
7.

Dependence

The psychological or physiological need to take a substance in oder to experience its effects or to avoid the effects of its absence. [from NCI]

MedGen UID:
141006
Concept ID:
C0439857
Mental or Behavioral Dysfunction
8.

Opiate

sedative narcotics containing opium [from CHV]

MedGen UID:
138150
Concept ID:
C0376196
Hazardous or Poisonous Substance; Pharmacologic Substance
9.

Abnormal

Deviating in any way from the state, position, structure, condition, behavior, or rule which is considered a norm. (NCI) [from NCI_CDISC]

MedGen UID:
59964
Concept ID:
C0205161
Finding
10.

Diagnosis, Psychiatric

MedGen UID:
138165
Concept ID:
C0376338
Mental or Behavioral Dysfunction
11.

Genetic predisposition

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. [from MeSH]

MedGen UID:
137259
Concept ID:
C0314657
Organism Attribute
12.

Substance-Related Disorders

Disorders related to substance abuse. [from MeSH]

MedGen UID:
66746
Concept ID:
C0236969
Mental or Behavioral Dysfunction
13.

Endopeptidases

nonEC category which corresponds to EC 3.4.21, EC 3.4.22, EC 3.4.23, EC 3.4.24, and EC 3.4.99. [from CRISP]

MedGen UID:
45389
Concept ID:
C0030946
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
14.

Mental disorder

Mental disorders include a wide range of problems, including. -Anxiety disorders, including panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and phobias. -Bipolar disorder. -Depression. -Mood disorders. -Personality disorders. -Psychotic disorders, including schizophrenia. There are many causes of mental disorders. Your genes and family history may play a role. Your life experiences, such as stress or a history of abuse, may also matter. Biological factors can also be part of the cause. A traumatic brain injury can lead to a mental disorder. A mother's exposure to viruses or toxic chemicals while pregnant may play a part. Other factors may increase your risk, such as use of illegal drugs or having a serious medical condition like cancer. Medications and counseling can help many mental disorders. .  [from MedlinePlus]

MedGen UID:
14047
Concept ID:
C0004936
Mental or Behavioral Dysfunction
15.

Opioid-induced organic mental disorder

Disorders related or resulting from abuse or mis-use of opioids. [from MeSH]

MedGen UID:
10264
Concept ID:
C0027412
Mental or Behavioral Dysfunction
16.

Opioid-Related Disorders

MedGen UID:
880961
Concept ID:
CN236652
Disease or Syndrome
17.

Min-I-Jet Morphine Sulphate

MedGen UID:
109224
Concept ID:
C0591798
Organic Chemical; Pharmacologic Substance
18.

Cortical visual impairment

A form of loss of vision caused by damage to the visual cortex rather than a defect in the eye. [from HPO]

MedGen UID:
66699
Concept ID:
C0234398
Disease or Syndrome
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