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Items: 1 to 20 of 32

1.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Neuroreactive Substance or Biogenic Amine; Organic Chemical; Pharmacologic Substance
2.

Apomorphine

A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. [from MeSH]

MedGen UID:
1627
Concept ID:
C0003596
Organic Chemical; Pharmacologic Substance
3.

agonists

Used with chemicals, drugs, and endogenous substances to indicate substances or agents that have affinity for a receptor and intrinsic activity at that receptor. (From Textbook of Pharmacology, 1991, p.16) [from MeSH]

MedGen UID:
116746
Concept ID:
C0243192
Pharmacologic Substance
4.

Quinpirole

A dopamine D2/D3 receptor agonist. [from MeSH]

MedGen UID:
75025
Concept ID:
C0072892
Organic Chemical; Pharmacologic Substance
5.

Haloperidol

A phenylbutylpiperadine derivative with antipsychotic, neuroleptic, and antiemetic activities. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain, thereby eliminating dopamine neurotransmission and leading to antidelusionary and antihallucinagenic effects. Antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) accounts for its antiemetic activity. [from NCI]

MedGen UID:
42327
Concept ID:
C0018546
Organic Chemical; Pharmacologic Substance
6.

Phosphorylation

A process in which a phosphate group is added to a molecule, such as a sugar or a protein. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
7.

brain-derived neurotrophic factor, human

Brain-derived neurotrophic factor (247 aa, ~28 kDa) is encoded by the human BDNF gene. This protein plays a role in both the development of the nervous system and neuronal survival. [from NCI]

MedGen UID:
760637
Concept ID:
C3486709
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
8.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
9.

Agonist

A drug or substance that binds to a receptor inside a cell or on its surface and causes the same action as the substance that normally binds to the receptor. [from NCI]

MedGen UID:
459858
Concept ID:
C2987634
Pharmacologic Substance
10.

Dopamine D2 Receptor Antagonists

Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS. [from MeSH]

MedGen UID:
827193
Concept ID:
C3850099
Pharmacologic Substance
11.

Metabolic Networks and Pathways

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites. [from MeSH]

MedGen UID:
328456
Concept ID:
C1721099
Molecular Function
12.

Apomorphin-Teclapharm

MedGen UID:
253309
Concept ID:
C1448441
Organic Chemical; Pharmacologic Substance
13.

Apokinon

MedGen UID:
253308
Concept ID:
C1448440
Organic Chemical; Pharmacologic Substance
14.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
15.

MAP Kinase Signaling System

An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. [from MeSH]

MedGen UID:
155748
Concept ID:
C0752321
Molecular Function
16.

Intropin

MedGen UID:
147406
Concept ID:
C0721081
Organic Chemical; Pharmacologic Substance
17.

Dopamine antagonist

Any agent that binds to and blocks dopamine receptors. [from NCI]

MedGen UID:
116643
Concept ID:
C0242702
Biologically Active Substance; Neuroreactive Substance or Biogenic Amine; Pharmacologic Substance
18.

Britaject

MedGen UID:
108350
Concept ID:
C0591195
Organic Chemical; Pharmacologic Substance
19.

Neurotransmitter Agents

Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. [from MeSH]

MedGen UID:
69321
Concept ID:
C0243051
Pharmacologic Substance
20.

Anti-Dyskinesia Agents

Drugs used in the treatment of movement disorders. Most of these act centrally on dopaminergic or cholinergic systems. Among the most important clinically are those used for the treatment of Parkinson disease (ANTIPARKINSON AGENTS) and those for the tardive dyskinesias. [from MeSH]

MedGen UID:
69299
Concept ID:
C0242951
Pharmacologic Substance
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