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Items: 8

1.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
2.

Papillary thyroid carcinoma

Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular (188470), Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100; Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). PTC is characterized by distinctive nuclear alterations including pseudoinclusions, grooves, and chromatin clearing. PTCs smaller than 1 cm are referred to as papillary microcarcinomas. These tumors have been identified in up to 35% of individuals at autopsy, suggesting that they may be extremely common although rarely clinically relevant. PTC can also be multifocal but is typically slow-growing with a tendency to spread to lymph nodes and usually has an excellent prognosis (summary by Bonora et al., 2010). Genetic Heterogeneity of Susceptibility to Nonmedullary Thyroid Cancer Other susceptibilities to nonmedullary thyroid cancer include NMTC2 (188470), caused by mutation in the SRGAP1 gene (606523); NMTC3 (606240), mapped to chromosome 2q21; NMTC4 (616534), caused by mutation in the FOXE1 gene (602617); and NMTC5 (616535), caused by mutation in the HABP2 gene (603924). A susceptibility locus for familial nonmedullary thyroid carcinoma with or without cell oxyphilia (TCO; 603386) has been mapped to chromosome 19p. [from OMIM]

MedGen UID:
66773
Concept ID:
C0238463
Neoplastic Process
3.

Carmol

MedGen UID:
152591
Concept ID:
C0728793
Organic Chemical; Pharmacologic Substance
4.

Basodexan

MedGen UID:
147554
Concept ID:
C0729126
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
5.

Urea

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. [from MeSH]

MedGen UID:
21773
Concept ID:
C0041942
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
6.

Thiourea tasting

MedGen UID:
1461293
Concept ID:
CN806888
Finding
7.

Sensory function status

Extent to which an individual correctly perceives skin stimulation, sounds, proprioception, taste and smell, and visual images [from NOC]

MedGen UID:
729613
Concept ID:
C1320986
Finding
8.

Thiourea tasting

MedGen UID:
358312
Concept ID:
C1868397
Finding
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