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Items: 4

1.

Irritability

Feelings of annoyance, impatience, and anger. [from NCI]

MedGen UID:
397841
Concept ID:
C2700617
Mental Process
2.

Feeling irritable

Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience. [from MeSH]

MedGen UID:
5898
Concept ID:
C0022107
Finding
3.

Staphylococcus haemolyticus

A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION). [from MeSH]

MedGen UID:
137369
Concept ID:
C0318114
Bacterium; Pharmacologic Substance
4.

Lapachone

A poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. Beta-lapachone (b-lap) is bioactivated by NAD(P)H:quinone oxidoreductase-1 (NQO1), creating a futile oxidoreduction that generates high levels of superoxide. In turn, the highly reactive oxygen species (ROS) interact with DNA, thereby causing single-strand DNA breaks and calcium release from endoplasmic reticulum (ER) stores. Eventually, the extensive DNA damage causes hyperactivation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme facilitating DNA repair, accompanied by rapid depletion of NAD+/ATP nucleotide levels. As a result, a caspase-independent and ER-stress induced mu-calpain-mediated cell death occurs in NQO1-overexpressing tumor cells. NQO1, a flavoprotein and two-electron oxidoreductase, is overexpressed in a variety of tumors. [from NCI]

MedGen UID:
14991
Concept ID:
C0053471
Organic Chemical; Pharmacologic Substance
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