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Items: 1 to 20 of 37

1.

Inflammation

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
2.

Crohn disease

MedGen UID:
909933
Concept ID:
CN043071
Disease or Syndrome
3.

Acute inflammation

A morphologic finding indicating the presence of neutrophils and/or eosinophils in a tissue sample. [from NCI]

MedGen UID:
87166
Concept ID:
C0333361
Finding
4.

Crohn disease

A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation. [from HPO]

MedGen UID:
3664
Concept ID:
C0010346
Disease or Syndrome
5.

Sildenafil

A drug used to treat erectile dysfunction. Sildenafil relaxes the smooth muscle of the penis to allow increased blood flow and erection. It is a type of phosphodiesterase inhibitor. [from NCI_NCI-GLOSS]

MedGen UID:
102095
Concept ID:
C0529793
Organic Chemical; Pharmacologic Substance
6.

Nitric oxide

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. [from MeSH]

MedGen UID:
14378
Concept ID:
C0028128
Biologically Active Substance; Inorganic Chemical; Pharmacologic Substance
7.

Granuloma

A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents. [from MeSH]

MedGen UID:
5376
Concept ID:
C0018188
Pathologic Function
8.

Chronic disease

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed) [from MeSH]

MedGen UID:
3453
Concept ID:
C0008679
Disease or Syndrome
9.

Accumulation

A state characterized by the gradual increase in entities or substances. [from NCI]

MedGen UID:
883922
Concept ID:
C4055506
Finding
10.

Impairment

MedGen UID:
151925
Concept ID:
C0684336
Pathologic Function
11.

Chronic

Slow, creeping onset, slow progress and long continuance of disease manifestations. [from HPO]

MedGen UID:
104657
Concept ID:
C0205191
Temporal Concept
12.

Ameliorated by

An ameliorating factor is defined as an external factor that leads to the manifestation of a sign or symptom in a person improving or becoming more bearable. [from HPO]

MedGen UID:
83049
Concept ID:
C0332161
Qualitative Concept
13.

Recruitment

MedGen UID:
78772
Concept ID:
C0271510
Disease or Syndrome
14.

Lesion

A localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part. [from NCI]

MedGen UID:
65128
Concept ID:
C0221198
Finding
15.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
16.

Immunodeficiency

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral. [from MeSH]

MedGen UID:
7034
Concept ID:
C0021051
Disease or Syndrome
17.

Chronic inflammation

MedGen UID:
5797
Concept ID:
C0021376
Pathologic Function
18.

Ileocolitis

MedGen UID:
184943
Concept ID:
C0949272
Disease or Syndrome
19.

Inflammatory bowel disease 1

MedGen UID:
146259
Concept ID:
C0678202
Disease or Syndrome
20.

Crohn disease of ileum

Chrohn's disease affecting the ileum. [from NCI]

MedGen UID:
82754
Concept ID:
C0267380
Disease or Syndrome
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