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1.

Venous Thromboembolism

Occlusion of the lumen of a vein by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
348285
Concept ID:
C1861172
Disease or Syndrome
2.

Combined oral contraceptive

Fixed drug combinations administered orally for contraceptive purposes. [from MeSH]

MedGen UID:
40473
Concept ID:
C0009906
Pharmacologic Substance
3.

Thromboembolism

Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream. [from MeSH]

MedGen UID:
21532
Concept ID:
C0040038
Finding; Pathologic Function
4.

Coagulation factor II

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia. [from MeSH]

MedGen UID:
19527
Concept ID:
C0033706
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
5.

Pregnancy

The state or condition of having a developing embryo or fetus in the body (uterus), after union of an ovum and spermatozoon, during the period from conception to birth. [from NCI]

MedGen UID:
10895
Concept ID:
C0032961
Organism Function
6.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
505000
Concept ID:
CN001725
Finding
7.

Factor V Leiden mutation

An abnormality that refers to mutation of factor V Leiden, which is a variant of human factor V. It results in thrombophilia, deep vein thrombosis, and a slightly increased risk of miscarriage. [from NCI]

MedGen UID:
473218
Concept ID:
C0584960
Disease or Syndrome
8.

Prothrombin

MedGen UID:
417935
Concept ID:
C2828369
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
9.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele in F2 never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders (e.g., antiphospholipid antibodies). Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GTR]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
10.

Tetrahydrofolate

biologically active form of folate. [from CRISP]

MedGen UID:
901093
Concept ID:
C4082270
Organic Chemical; Pharmacologic Substance
11.

Nadroparin calcium

A heparin fraction with a mean molecular weight of 4500 daltons. It is isolated from porcine mucosal heparin and used as an antithrombotic agent. (From Merck Index, 11th ed) [from MeSH]

MedGen UID:
60103
Concept ID:
C0206232
Organic Chemical; Pharmacologic Substance
12.

Protein C

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation. [from MeSH]

MedGen UID:
46154
Concept ID:
C0033621
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
13.

Heparin

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. [from MeSH]

MedGen UID:
42413
Concept ID:
C0019134
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
14.

Venous thrombosis

Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow. [from HPO]

MedGen UID:
22631
Concept ID:
C0042487
Pathologic Function
15.

Thrombosis

Formation and development of a thrombus or blood clot in the blood vessel. [from MeSH]

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
16.

Antithrombin III preparation

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily. [from MeSH]

MedGen UID:
1993
Concept ID:
C0003438
Amino Acid, Peptide, or Protein; Pharmacologic Substance
17.

Anticoagulant

Agents that prevent BLOOD CLOTTING. [from MeSH]

MedGen UID:
1970
Concept ID:
C0003280
Pharmacologic Substance
18.

Contraceptives, Oral, Hormonal

Oral contraceptives which owe their effectiveness to hormonal preparations. [from MeSH]

MedGen UID:
1114
Concept ID:
C0009907
Pharmacologic Substance
19.

Caesarian section

Extraction of the FETUS by means of abdominal HYSTEROTOMY. [from MeSH]

MedGen UID:
863
Concept ID:
C0007876
Therapeutic or Preventive Procedure
20.

Lupus anticoagulant

MedGen UID:
1370558
Concept ID:
C4321325
Finding
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