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Items: 12

1.

Neuroblastoma

ALK-related neuroblastic tumor susceptibility results from heterozygosity for a germline ALK activating pathogenic variant in the tyrosine kinase domain that predisposes to neuroblastic tumors. The spectrum of neuroblastic tumors includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Neuroblastoma is a more malignant tumor and ganglioneuroma a more benign tumor. Depending on the histologic findings ganglioneuroblastoma can behave in a more aggressive fashion, like neuroblastoma, or in a benign fashion, like ganglioneuroma. At present there are no data regarding the lifetime risk to an individual with a germline ALK pathogenic variant of developing a neuroblastic tumor. Preliminary data from the ten reported families with ALK-related neuroblastic tumor susceptibility suggest that the overall penetrance is around 57% with the risk for neuroblastic tumor development highest in infancy and decreasing by late childhood. [from GTR]

MedGen UID:
18012
Concept ID:
C0027819
Neoplastic Process
2.

Cyclophosphamide

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. [from NCI]

MedGen UID:
4107
Concept ID:
C0010583
Organic Chemical; Pharmacologic Substance
3.

Neuroblastoma

Neuroblastoma is a malignant tumor of neural crest cells, the cells that give rise to the sympathetic nervous system, which is observed in children. [from ORDO]

MedGen UID:
798120
Concept ID:
CN205405
Disease or Syndrome
4.

Neuroblastoma

Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum. [from HPO]

MedGen UID:
505432
Concept ID:
CN002717
Finding
5.

Monoclonal Antibody 3F8

A murine monoclonal antibody directed against the cell-surface, tumor-associated antigen ganglioside GD2. Vaccination with monoclonal antibody 3F8 may stimulate a host cytotoxic immune response against tumors that express ganglioside GD2. (NCI04) [from NCI]

MedGen UID:
79200
Concept ID:
C0280849
Amino Acid, Peptide, or Protein; Immunologic Factor; Pharmacologic Substance
6.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
7.

Tespamin

MedGen UID:
196420
Concept ID:
C0729087
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
8.

Tespa

MedGen UID:
152633
Concept ID:
C0729086
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
9.

NSC-6396

MedGen UID:
152631
Concept ID:
C0729084
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
10.

Girostan

MedGen UID:
152630
Concept ID:
C0729083
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
11.

AI3-24916

MedGen UID:
149058
Concept ID:
C0729081
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
12.

Aziridine, 1,1',1''-phosphinylidynetris-

An insect chemosterilant and an antineoplastic agent. [from MeSH]

MedGen UID:
21096
Concept ID:
C0039533
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
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