Format
Items per page

Send to:

Choose Destination

Links from PubMed

Items: 1 to 20 of 53

1.

Leiomyomatosis

A condition characterized by the presence of numerous small benign smooth muscle neoplasms located throughout the body. [from NCI]

MedGen UID:
60203
Concept ID:
C0206654
Neoplastic Process
2.

Hereditary leiomyomatosis and renal cell cancer

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is characterized by cutaneous leiomyomata (multiple or single in 76% of affected individuals), uterine leiomyomata (fibroids), and/or a single renal tumor. Cutaneous leiomyomata appear as skin-colored to light brown papules or nodules distributed over the trunk and extremities, and occasionally on the face, and appear at a mean age of 25 years, increasing in size and number with age. Uterine leiomyomata are present in almost all females with HLRCC and tend to be numerous and large; age at diagnosis ranges from 18 to 52 years, with most women experiencing irregular or heavy menstruation and pelvic pain. Renal tumors causing hematuria, lower back pain, and a palpable mass are usually unilateral, solitary, and aggressive and range from type 2 papillary to tubulo-papillary to collecting-duct carcinomas. They occur in about 10%-16% of individuals with HLRCC; the median age of detection is 44 years. [from GTR]

MedGen UID:
353771
Concept ID:
C1708350
Neoplastic Process
3.

Papillary renal cell carcinoma

A rare subtype of renal cell carcinoma arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with haematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes may predispose to the development of papillary renal cell carcinoma. [from SNOMEDCT_US]

MedGen UID:
266300
Concept ID:
C1306837
Neoplastic Process
4.

Phenoxybenzamine

A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. [from NCI]

MedGen UID:
45857
Concept ID:
C0031441
Organic Chemical; Pharmacologic Substance
5.

Pain

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. [from MeSH]

MedGen UID:
45282
Concept ID:
C0030193
Sign or Symptom
6.

Nifedipine

A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) [from NCI]

MedGen UID:
45090
Concept ID:
C0028066
Organic Chemical; Pharmacologic Substance
7.

Syndrome

A characteristic symptom complex. [from MeSH]

MedGen UID:
11688
Concept ID:
C0039082
Disease or Syndrome
8.

Carcinoma

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." [from MeSH]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
9.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
10.

Pain

MedGen UID:
880950
Concept ID:
CN236637
Disease or Syndrome
11.

Renal cell carcinoma

MedGen UID:
775811
Concept ID:
CN182935
Disease or Syndrome
12.

Left

Being located on the left side of the body. [from HPO]

MedGen UID:
618170
Concept ID:
C0443246
Spatial Concept
13.

Borries syndrome

MedGen UID:
542920
Concept ID:
C0270677
Disease or Syndrome
14.

Fumarate

MedGen UID:
526117
Concept ID:
C0220833
Organic Chemical; Pharmacologic Substance
15.

Papule

A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point. [from HPO]

MedGen UID:
507324
Concept ID:
C0332563
Finding
16.

Renal cell carcinoma

A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule. [from HPO]

MedGen UID:
505836
Concept ID:
CN004944
Finding
17.

Novel Mutation

A newly discovered, distinct gene alteration; NOT the same as new or de novo mutation. [from NCI_NCI-GLOSS]

MedGen UID:
457664
Concept ID:
C2985438
Cell or Molecular Dysfunction
18.

History

The aggregate of past events; the continuum of events occurring in succession leading from the past to the present; a record or narrative description of past events. [from NCI]

MedGen UID:
389153
Concept ID:
C2004062
Finding
19.

Proliferation

MedGen UID:
137720
Concept ID:
C0334094
Pathologic Function
20.

Cutaneous leiomyoma

A benign smooth muscle neoplasm arising from the arrector pili muscle, tunica media of blood vessels, and dartos muscle of the genitalia. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

MedGen UID:
87533
Concept ID:
C0346064
Neoplastic Process
Format
Items per page

Send to:

Choose Destination

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center