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Items: 4

1.

Insulin Glargine

A recombinant human insulin analog with long-acting, blood glucose-lowering activity. Insulin glargine, like regular types of human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin glargine inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin glargine also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. (NCI05) [from NCI]

MedGen UID:
172793
Concept ID:
C0907402
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
2.

exenatide

A 39 amino acid peptide and synthetic version of exendin-4, a hormone found in the saliva of the venomous lizard Gila monster, with insulin secretagogue and antihyperglycemic activity. Exenatide is administered subcutaneously and mimics human glucagon-like peptide-1 (GLP-1). Compared to GLP-1, exenatide has a longer half-life of 2.4 hours. [from NCI]

MedGen UID:
104090
Concept ID:
C0167117
Amino Acid, Peptide, or Protein; Pharmacologic Substance
3.

Insulin

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. [from NCI]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
4.

Nocturnal hypoglycemia

MedGen UID:
574951
Concept ID:
C0342315
Pathologic Function
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