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Items: 4

1.

tocotrienol, alpha

MedGen UID:
65751
Concept ID:
C0217873
Organic Chemical; Pharmacologic Substance
2.

Vitamin E

A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS. [from MeSH]

MedGen UID:
12116
Concept ID:
C0042874
Organic Chemical; Pharmacologic Substance; Vitamin
3.

Tocotrienol

Any of the four forms, alpha, beta, gamma and delta, of a member of the vitamin E family, with potential hypocholesterolemic, antithrombotic, antioxidant, immunomodulating and antineoplastic activities. Tocotrienol inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, thereby lowering cholesterol levels. In addition, tocotrienol acts through multiple signal transduction pathways to induce cell cycle arrest and caspase-mediated apoptosis, and to decrease tumor cell proliferation. In addition, this agent may inhibit angiogenesis through the blockage of vascular endothelial growth factor receptor (VEGFR) and the subsequent inhibition of tumor cell-induced vessel formation. Also, this agent prevents free radical formation and inhibits lipid peroxidation, thereby preventing DNA cell damage. Tocotrienol farnesyl isoprenoid side chains contain 3 double bonds, which are absent in tocopherols, likely contribute to its anti-cancer activities. [from NCI]

MedGen UID:
215408
Concept ID:
C0949647
Organic Chemical; Pharmacologic Substance; Vitamin
4.

Vitamin preparation

A group of organic food substances found in animals and plants in small quantities. They must be supplied in diet or dietary supplement and are essential for normal metabolism. [from NCI]

MedGen UID:
12117
Concept ID:
C0042890
Organic Chemical; Pharmacologic Substance; Vitamin
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