Format

Send to:

Choose Destination

Links from PubMed

Gardner syndrome(GS)

MedGen UID:
6547
Concept ID:
C0017097
Disease or Syndrome
Synonyms: Gardner's syndrome; GS; Intestinal polyposis, osteomas, sebaceous cysts; Polyposis coli and multiple hard and soft tissue tumors
SNOMED CT: Gardner syndrome (60876000); GS - Gardner's syndrome (60876000)
 
Orphanet: ORPHA79665

Definition

A variant of familial adenomatous polyposis. It is an autosomal dominant syndrome characterized by multiple colonic polyps predisposing to carcinoma of the colon, osteomas of the skull, epidermoid cysts, and fibromas. It is associated with mutation of the APC gene. [from NCI]

Professional guidelines

PubMed

Church J, Lowry A, Simmang C; Standards Task Force.; American Society of Colon and Rectal Surgeons.
Dis Colon Rectum 2001 Oct;44(10):1404-12. PMID: 11598466

Recent clinical studies

Etiology

Turina M, Pavlik CM, Heinimann K, Behrensmeier F, Simmen HP
Int J Colorectal Dis 2013 Jun;28(6):865-72. Epub 2012 Nov 1 doi: 10.1007/s00384-012-1600-x. PMID: 23114473
Filipe B, Albuquerque C, Bik E, Lage P, Rodrigues P, Vossen R, Tops C, Nobre Leitão C
Dis Colon Rectum 2009 Aug;52(8):1516-20; discussion 1520-1. doi: 10.1007/DCR.0b013e3181ab810f. PMID: 19617769
Lee BD, Lee W, Oh SH, Min SK, Kim EC
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 Mar;107(3):e68-72. Epub 2009 Jan 20 doi: 10.1016/j.tripleo.2008.10.018. PMID: 19157925
Bilkay U, Erdem O, Ozek C, Helvaci E, Kilic K, Ertan Y, Gurler T
J Craniofac Surg 2004 May;15(3):506-9. PMID: 15111819
Burke MP, Opeskin K
Am J Forensic Med Pathol 2001 Mar;22(1):84-7. PMID: 11444670

Diagnosis

Pena AH, Chaudhry A, Seidman RJ, Peyster R, Bangiyev L
Clin Imaging 2016 Mar-Apr;40(2):232-6. Epub 2015 Nov 19 doi: 10.1016/j.clinimag.2015.11.005. PMID: 26995577
Fitzpatrick SG, Hirsch SA, Listinsky CM, Lyu DJ, Baur DA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Apr;119(4):e241-5. Epub 2014 Sep 30 doi: 10.1016/j.oooo.2014.09.028. PMID: 25434693
Brown CS, Jeffrey B, Korentager R, Hughes K
Ann Plast Surg 2012 Aug;69(2):220-2. doi: 10.1097/SAP.0b013e31821e8faf. PMID: 21629058
Bozbuga M, Turan Suslu H, Hicdonmez T, Bayindir C
J Clin Neurosci 2011 Feb;18(2):300-1. Epub 2011 Jan 7 doi: 10.1016/j.jocn.2010.06.006. PMID: 21216148
Juhn E, Khachemoune A
Am J Clin Dermatol 2010;11(2):117-22. doi: 10.2165/11311180-000000000-00000. PMID: 20141232

Therapy

Lauro A, Zanfi C, Dazzi A, di Gioia P, Stanghellini V, Pironi L, Ercolani G, Gaudio MD, Ravaioli M, Faenza S, di Simone M, Pinna AD
Transplant Proc 2014 Jan-Feb;46(1):245-8. doi: 10.1016/j.transproceed.2013.08.110. PMID: 24507060
Turina M, Pavlik CM, Heinimann K, Behrensmeier F, Simmen HP
Int J Colorectal Dis 2013 Jun;28(6):865-72. Epub 2012 Nov 1 doi: 10.1007/s00384-012-1600-x. PMID: 23114473
Gu GL, Wang SL, Wei XM, Bai L
World J Gastroenterol 2008 Apr 7;14(13):2121-3. PMID: 18395919Free PMC Article
Ishida T, Abe S, Miki Y, Imamura T
Skeletal Radiol 2007 Jul;36(7):693-8. Epub 2007 Jan 18 doi: 10.1007/s00256-006-0264-4. PMID: 17235575
Herrmann SM, Adler YD, Schmidt-Petersen K, Nicaud V, Morrison C, Paul M, Zouboulis ChC
Br J Dermatol 2003 Oct;149(4):877-83. PMID: 14616385

Prognosis

Ponti G, Tomasi A, Manfredini M, Pellacani G
Gene 2016 May 10;582(1):23-32. Epub 2016 Feb 3 doi: 10.1016/j.gene.2016.01.053. PMID: 26850131
Cobianchi L, Ravetta V, Viera FT, Filisetti C, Siri B, Segalini E, Maestri M, Dominioni T, Alessiani M, Rossi S, Dionigi P
World J Surg Oncol 2014 Nov 27;12:361. doi: 10.1186/1477-7819-12-361. PMID: 25429890Free PMC Article
Kim MS, Kim YS, Lee HK, Lee GJ, Choi CY, Lee CH
J Neurosurg 2014 Feb;120(2):337-41. Epub 2013 Nov 22 doi: 10.3171/2013.10.JNS131401. PMID: 24266539
Filipe B, Albuquerque C, Bik E, Lage P, Rodrigues P, Vossen R, Tops C, Nobre Leitão C
Dis Colon Rectum 2009 Aug;52(8):1516-20; discussion 1520-1. doi: 10.1007/DCR.0b013e3181ab810f. PMID: 19617769
Link MJ, Driscoll CL, Giannini C
Neurosurgery 2002 Jul;51(1):221-5; discussion 225-6. PMID: 12182421

Clinical prediction guides

Ponti G, Tomasi A, Manfredini M, Pellacani G
Gene 2016 May 10;582(1):23-32. Epub 2016 Feb 3 doi: 10.1016/j.gene.2016.01.053. PMID: 26850131
Casper M, Petek E, Henn W, Niewald M, Schneider G, Zimmer V, Lammert F, Raedle J
QJM 2014 Jul;107(7):521-7. Epub 2014 Feb 18 doi: 10.1093/qjmed/hcu036. PMID: 24554300
Filipe B, Albuquerque C, Bik E, Lage P, Rodrigues P, Vossen R, Tops C, Nobre Leitão C
Dis Colon Rectum 2009 Aug;52(8):1516-20; discussion 1520-1. doi: 10.1007/DCR.0b013e3181ab810f. PMID: 19617769
Ishida T, Abe S, Miki Y, Imamura T
Skeletal Radiol 2007 Jul;36(7):693-8. Epub 2007 Jan 18 doi: 10.1007/s00256-006-0264-4. PMID: 17235575
Davies DR, Armstrong JG, Thakker N, Horner K, Guy SP, Clancy T, Sloan P, Blair V, Dodd C, Warnes TW
Am J Hum Genet 1995 Nov;57(5):1151-8. PMID: 7485167Free PMC Article

Recent systematic reviews

Balzer BL, Weiss SW
Hum Pathol 2009 Nov;40(11):1564-70. Epub 2009 Jun 21 doi: 10.1016/j.humpath.2009.03.020. PMID: 19540553
Bilkay U, Erdem O, Ozek C, Helvaci E, Kilic K, Ertan Y, Gurler T
J Craniofac Surg 2004 May;15(3):506-9. PMID: 15111819

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center