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Items: 1 to 20 of 29

1.

Venous Thromboembolism

Occlusion of the lumen of a vein by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
348285
Concept ID:
C1861172
Pathologic Function
2.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele in F2 never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders (e.g., antiphospholipid antibodies). Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GeneReviews]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
3.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
21532
Concept ID:
C0040038
Finding; Pathologic Function
4.

Thrombosis

The formation or presence of a thrombus (blood clot) inside a blood vessel. [from NCI]

MedGen UID:
21160
Concept ID:
C0040053
Pathologic Function
5.

Contraceptives, Oral

An agent taken orally to prevent conception. [from NCI]

MedGen UID:
1113
Concept ID:
C0009905
Pharmacologic Substance
6.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
505000
Concept ID:
CN001725
Finding
7.

Hypercoagulability

MedGen UID:
463623
Concept ID:
C3160733
Finding
8.

Contraceptive Agents

agent that diminishes the likelihood of or prevents conception; may be chemical, physical, or behavioral. [from CRISP]

MedGen UID:
40468
Concept ID:
C0009871
Pharmacologic Substance
9.

CI 4

MedGen UID:
94875
Concept ID:
C0387382
Amino Acid, Peptide, or Protein; Pharmacologic Substance
10.

Protein C

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation. [from MeSH]

MedGen UID:
46154
Concept ID:
C0033621
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
11.

Combined oral contraceptive

Fixed drug combinations administered orally for contraceptive purposes. [from MeSH]

MedGen UID:
40473
Concept ID:
C0009906
Pharmacologic Substance
12.

TO 115

MedGen UID:
37714
Concept ID:
C0076769
Organic Chemical; Pharmacologic Substance
13.

Coagulation factor II

Prothrombin (622 aa, ~70 kDa) is encoded by the human F2 gene. This protein plays a role in both coagulation and proteolysis of fibrinogen. [from NCI]

MedGen UID:
19527
Concept ID:
C0033706
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
14.

Factor V Leiden mutation

An abnormality that refers to mutation of factor V Leiden, which is a variant of human factor V. It results in thrombophilia, deep vein thrombosis, and a slightly increased risk of miscarriage. [from NCI]

MedGen UID:
473218
Concept ID:
C0584960
Disease or Syndrome
15.

Coagulation Factor II Human

MedGen UID:
417935
Concept ID:
C2828369
Amino Acid, Peptide, or Protein; Biologically Active Substance; Organic Chemical; Pharmacologic Substance
16.

Antithrombins

endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin; includes fibrin and antithrombin III. [from CRISP]

MedGen UID:
354
Concept ID:
C0003440
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
17.

Thrombus

MedGen UID:
43439
Concept ID:
C0087086
Disease or Syndrome; Pathologic Function
18.

Embolism and Thrombosis

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
43147
Concept ID:
C0085307
Disease or Syndrome
19.

Venous thrombosis

Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow. [from HPO]

MedGen UID:
22631
Concept ID:
C0042487
Pathologic Function
20.

Vascular disorder

The vascular system is the body's network of blood vessels. It includes the arteries, veins and capillaries that carry blood to and from the heart. Problems of the vascular system are common and can be serious. Arteries can become thick and stiff, a problem called atherosclerosis. Blood clots can clog vessels and block blood flow to the heart or brain. Weakened blood vessels can burst, causing bleeding inside the body. . You are more likely to have vascular disease as you get older. Other factors that make vascular disease more likely include. - Family history of vascular or heart diseases. - Pregnancy. - Illness or injury . - Long periods of sitting or standing still. - Any condition that affects the heart and blood vessels, such as diabetes or high cholesterol . - Smoking . - Obesity . Losing weight, eating healthy foods, being active and not smoking can help vascular disease. Other treatments include medicines and surgery.  [from MedlinePlus]

MedGen UID:
22621
Concept ID:
C0042373
Disease or Syndrome
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